文章摘要
李永飞,唐 敏,王尚乾,宋国新,张 炜.PTEN和P53在非肌层浸润性膀胱肿瘤中的表达及临床意义[J].南京医科大学学报,2013,(5):636~640
PTEN和P53在非肌层浸润性膀胱肿瘤中的表达及临床意义
Expressions and clinical significances of PTEN and P53 gene in non-muscle-invasive bladder cancer
投稿时间:2012-12-07  
DOI:10.7655/NYDXBNS20130514
中文关键词: 膀胱肿瘤  PTEN  P53  免疫组化
英文关键词: bladder carcinoma  PTEN  P53  immunochemistry
基金项目:国家自然科学基金(81170612)
作者单位
李永飞 南京医科大学第一附属医院泌尿外科,江苏 南京 210029 
唐 敏 南京医科大学第一附属医院泌尿外科,江苏 南京 210029 
王尚乾 南京医科大学第一附属医院泌尿外科,江苏 南京 210029 
宋国新 南京医科大学第一附属医院病理科,江苏 南京 210029 
张 炜 南京医科大学第一附属医院泌尿外科,江苏 南京 210029 
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中文摘要:
      目的:探讨非肌层浸润性膀胱尿路上皮肿瘤组织中PTEN和P53的表达及其临床意义。方法:采用免疫组化SP法,检测121例术前未经化疗患者膀胱癌组织中PTEN和P53的表达情况。进行临床资料随访,分析两者表达与肿瘤的分期?分级以及复发之间的关系。结果:121例标本中PTEN阳性表达89.2%,P53阳性表达39.6%。相关分析证明P53在T1期?高级别肿瘤中的表达明显,与肿瘤分期?分级呈正相关(P < 0.05),PTEN在T1期?高级别肿瘤中的表达较少,与肿瘤分期?分级呈负相关(P < 0.05)。生存分析显示膀胱癌的复发时间间隔与P53的表达有明显相关性,而与PTEN的表达无明显相关性。结论:PTEN?P53的阳性表达可能为明确膀胱肿瘤的生物学行为以及判断肿瘤术后复发提供依据。
英文摘要:
      Objective:To investigate the expression and significance of PTEN and P53 in non-muscle-invasive bladder cancer. Methods:The expression of PTEN and P53 in 121 cases of non-muscle-invasive bladder cancer tissues were determined by the immunochemical SP methods. We combined the clinical follow-up data to analye the relationship between these two markers with tumor stage, grade and recurrence. Results:The expressions of PTEN and P53 protein were detected in 89.2% and 39.6% of bladder cancer specimens, respectively. The positive expression rate of PTEN was negatively correlated with the pathological grades and clinical stages of bladder cancer. However, P53 was positively correlated with the pathological grades and clinical stages of bladder cancer. P53 was significantly correlation with the postoperative recurrence. No significant correlation between PTEN in non-muscle-invasive bladder cancer. Conclusion:The detection of the expression of PTEN and P53 in non-muscle-invasive bladder cancer is helpful to estimate the biological behavior and postoperative recurrence.
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