Objective:To investigate the metabolic characteristics of newly-diagnosed type 2 diabetes with nonalcoholic fatty liver disease(NAFLD) and the correlation between retinol binding protein 4 in newly-diagnosed type 2 diabetes with nonalcoholic fatty liver disease. Methods:A total of 216 patients with newly-diagnosed type 2 diabetes were enrolled in this study. They were divided into two groups according to with or without NAFLD. We compared the blood pressure,body mass index (BMI),blood lipids [TC,TG,HDL, LDL, Lp (a)], fasting glucose, fasting insulin, HbA1c,uric acid, liver function and retinol binding protein 4(RBP4). Logistic regression and Pearson correlation were performed to analyze the related factors. Results:The levels of BMI, systolic blood pressure, diastolic blood pressure were much higher in T2DM with NAFLD group than T2DM without NAFLD group. After adjustment of age,sex and BMI, the levels of triglyceride, total cholesterol, fasting insulin, insulin resistance index (HOMA-IR),ALT,γ-GGT, uric acid,RBP4 were significant higher in newly-diagnosed type 2 diabetes with NAFLD disease (P < 0.05). In logistic regression analysis,BMI,ALT and RBP4 were significant and independent predictors of newly-diagnosed type 2 diabetes with NAFLD(P < 0.05). RBP4 was significantly correlated with HOMA-IR,HbA1c,FINS,γ-GGT,UA (P < 0.05). Conclusion: The results suggest that newly-diagnosed type 2 diabetes with NAFLD displayed with the components of metabolic syndrome RBP4 may be an important indicator of nonalcoholic fatty liver disease in newly-diagnosed type 2 diabetes.