文章摘要
李 霞,刘晓梅,王 欣,丁虹娟,史爱武.妊娠期糖尿病血清NO、ET-1水平的变化及与脐血流阻力的关系[J].南京医科大学学报,2013,(5):658~661
妊娠期糖尿病血清NO、ET-1水平的变化及与脐血流阻力的关系
Changes of serum nitric oxide and endothelin-1 concentrations and its relationship with umbilical arteries blood flow velocity in pregnant women with gestational diabetes mellitus
投稿时间:2012-12-13  
DOI:10.7655/NYDXBNS20130519
中文关键词: 妊娠期糖尿病  一氧化氮  内皮素-1
英文关键词: gestational diabetes mellitus  nitric oxide  endothelin-1
基金项目:江苏省妇幼保健科研课题;南京市医学科技发展项目(YKK09086)
作者单位
李 霞 南京医科大学第四临床医学院,江苏 南京 210029
南京医科大学附属南京妇幼保健院产科,江苏 南京 210029 
刘晓梅 南京医科大学附属南京妇幼保健院产科,江苏 南京 210029 
王 欣 南京医科大学附属南京妇幼保健院产科,江苏 南京 210029 
丁虹娟 南京医科大学附属南京妇幼保健院产科,江苏 南京 210029 
史爱武 南京医科大学附属南京妇幼保健院重症监护病房,江苏 南京 210029 
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中文摘要:
      目的:测定妊娠期糖尿病患者血清一氧化氮(nitric oxide,NO)?内皮素-1(endothelin-1,ET-1)水平的变化,并探讨其与脐血流阻力的关系。方法:连续收集2012年1月~10月在南京医科大学附属南京妇幼保健院进行产前糖尿病筛查阳性和住院待产的45例妊娠期糖尿病妇女作为病例组,同期选择43例正常妊娠妇女作为对照组,在分娩前1周测定脐动脉血流阻力指数(S/D)值,孕妇住院待产时采集静脉血。分别采用硝酸还原酶法和ELISA法测定血清NO?ET-1含量。 结果:①与对照组相比,病例组的ET-1含量明显升高(P < 0.05),NO含量明显降低(P < 0.05),S/D值增加(P < 0.05),病例组孕妇静脉血NO含量和S/D呈负相关(r = -0.596,P < 0.05),而ET-1含量和S/D值呈正相关(r = 0.610,P < 0.05)。②病例组胎儿宫内缺氧?巨大儿?早产?羊水过多?妊娠期高血压的发生率和剖宫产率均高于对照组。结论:妊娠期糖尿病患者血清NO水平下降,ET-1水平增加,引起子宫-胎盘血流阻力的增加,可能是导致妊娠期糖尿病患者不良妊娠的一个重要因素。
英文摘要:
      Objective:To investigate the changes of serum nitric oxide (NO) and endothelin-1 (ET-1) concentrations and their relationship with umbilical arteries blood flow velocities in gestational diabetes mellitus(GDM) women. Methods:A total of 45 pregnant women with GDM were collected as the GDM group,and 43 normal pregnant(NP) women were selected as the control group. They were awaiting delivery during January to October in 2012. All of them underwent antepartum glucose tolerance test in their prenatal examination. Ultrasonic testing of cord blood flow parameters(S/D) were measured for the GDM group and control group at one week before delivery. Venous blood samples were collected from all the subjects when they were awaiting delivery in hospital. Venous blood NO and ET-1 levels were detected by nitrate reductase and ELISA,respectively. Results:Compared with the control group,venous blood NO levels decreased and ET-1 levels and S/D increased significantly (P < 0.05) in the GDM group (P < 0.05). NO level was negative (r = -0.596,P < 0.05) and ET-1 level was positive (r = 0.610,P < 0.05) related with S/D value in the GDM group. The incidence of adverse pregnancy in the GDM group was higher than the control group. Conclusion:The decrease of NO and the increase of ET-1 content lead to the increase of blood flow resistance of the fetal-placental,which may be an important factor leading to adverse pregnancy in patients with GDM.
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