鸡卵清蛋白上游启动子转录因子Ⅱ在人胃癌组织中的表达及临床意义
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国家自然科学基金面上项目(81072031)


Expression and clinical significance of chicken ovalbumin upstream promoter transcription factor Ⅱ protein in human gastric carcinoma tissues
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    目的:检测鸡卵清蛋白上游启动子转录因子Ⅱ(COUP-TFⅡ)在人胃癌组织中的表达,并探讨其临床意义及其影响胃癌发生-发展的可能分子机制。方法:收集66例手术切除的胃癌组织和相对应的癌旁非肿瘤组织标本,采用免疫组织化学法检测标本中COUP-TFⅡ和基质金属蛋白酶-2(MMP-2)蛋白的表达,分析COUP-TFⅡ与患者临床病理特征及预后之间的关系,以及COUP-TFⅡ与其潜在靶基因MMP-2的相关性。结果:COUP-TFⅡ蛋白在胃癌和癌旁组织中的阳性表达率分别为65.2%(43/66)和19.7%(13/66),两者比较差异有统计学意义(P < 0.05)。COUP-TFⅡ蛋白的表达与胃癌的浸润深度-分化程度-淋巴结转移及TNM分期密切相关(P < 0.05),而与患者的性别-年龄-肿瘤大小无关(P > 0.05)。COUP-TFⅡ蛋白阳性表达的患者术后平均生存时间比阴性表达者短,分别为(26.8 ± 2.6)个月和(36.4 ± 3.0)个月(χ2 = 4.118,P = 0.042)。MMP-2蛋白在胃癌和癌旁组织中的阳性表达率分别为78.8%(52/66)和34.8%(23/66),两者比较差异有统计学意义(P < 0.05)。COUP-TFⅡ 与MMP-2蛋白在胃癌组织中的表达呈正相关(r = 0.310,P = 0.011)。结论:COUP-TFⅡ蛋白与胃癌的发生-发展-侵袭-转移以及不良预后密切相关,推测可能是通过调控MMP-2的表达而发挥作用。

    Abstract:

    Objective:To detect the expression of chicken ovalbumin upstream promoter transcription factor Ⅱ(COUP-TFⅡ) protein in human gastric cancer(GC) tissues,and investigate the potential molecular mechanism of COUP-TFⅡ involved in the development and advancement of GC and its clinical significance. Methods:Paired tumorous and adjacent non-tumorous human gastric tissues were obtained from 66 patients with GC who underwent surgical resection. The expressions of COUP-TFⅡ and MMP-2 protein were detected using immunohistochemistry. The relationship between COUP-TFⅡ and the clinicopathologic factors as well as the correlation of COUP-TFⅡ and MMP-2 were analyzed. Results:COUP-TFⅡ proteins were positively expressed in 65.2%(43/66) and 19.7%(13/66) of GC tissues and paired non-GC tissues,respectively. The expression of COUP-TFⅡ was significantly correlated with the depth of invasion,differentiated grade,lymph node metastasis and tumor-node-metastatsis (TNM) stage (P < 0.05). However,the expression of COUP-TFⅡ was not correlated with the gender,age and volume of GC tissues. Patients with positive COUP-TFⅡ expression had lower mean survival time than those with negative COUP-TFⅡ expression (26.8 ± 2.6 months vs 36.4 ± 3.0 months, χ2 = 4.118,P = 0.042). MMP-2 proteins were positively expressed in 78.8% (52/66) and 34.8% (23/66) of GC tissues and paired non-GC tissues,respectively. Moreover,a positive correlation was found between COUP-TFⅡ and MMP-2 expression in GC tissues. Conclusion:COUP-TFⅡ protein has significant value in determining invasion and metastasis of gastric cancer and assessing prognosis in patients with gastric cancer,and MMP-2 may be involved in the above regulation progress.

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李增亮,姜宝飞,李 伟,徐 皓,徐泽宽.鸡卵清蛋白上游启动子转录因子Ⅱ在人胃癌组织中的表达及临床意义[J].南京医科大学学报(自然科学版),2013,(7):892-896

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  • 收稿日期:2013-05-20
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  • 在线发布日期: 2013-07-09
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