超敏C反应蛋白与出血性脑卒中的1∶2匹配病例对照研究
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A case-control study of high sensitive C-reactive protein level and hemorrhagic stroke
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    目的:探讨超敏C反应蛋白(hs-CRP)水平变化与出血性脑卒中的关系。方法:收集盐城市第一人民医院2009年住院的出血性脑卒中患者149例,同时选择同地区参与健康调查的社区人群作为对照,按同性别-同年龄(±2岁)进行1∶2匹配,共选择了298例非脑卒中对象作为对照。采用统一的流行病学调查表收集基本资料-个人疾病史,同时检测血压和血糖-血脂和hs-CRP等生化指标,应用Cox回归模型进行分析。结果:病例组hs-CRP水平显著高于对照组(P < 0.001);校正高血压史-糖尿病史-血糖和血脂升高等危险因素后,hs-CRP每升高1 mg/L的OR值(95%CI)为1.386(1.230~1.563),P < 0.001;而hs-CRP升高(≥3 mg/L)的OR值(95%CI)为6.599(3.141~13.867),P < 0.001。进一步按性别分层分析结果显示,男性hs-CRP升高(≥3 mg/L)者脑出血的患病风险高于女性,OR值(95%CI)分别为8.675(3.206~23.469)-3.836(1.106~13.308),P值分别为< 0.001-< 0.05。结论:hs-CRP升高与出血性脑卒中存在显著关联,且男女hs-CRP升高与出血性脑卒中的关联存在差异。

    Abstract:

    Objective:To investigate the association of plasma high sensitive C-reactive protein(hs-CRP) level and hemorrhagic stroke(HS). Methods:A case-control study(1∶2 matched) was conducted and 149 patients with acute cerebral hemorrhage from a county hospital and 298 age- and sex- matched controls from community-based population were selected in 2009. A unified questionnaire was managed to collect demographic information and history of disease. Blood pressure was measured and fasting glucose,plasma lipid and hs-CRP were detected. Cox model regression was applied to evaluate the association of hs-CRP level and hemorrhagic stroke. Results:The level of plasma hs-CRP in HS cases was significantly higher than that of controls (P < 0.001). The association of hs-CRP and HS was statistically significant and OR (95%CI) was 1.386 (1.230~1.563) for per 1 mg/L increasing (P < 0.001) after adjusted for histories of hypertension and diabetes,glucose and lipid. OR (95%CI) of hs-CRP elevation (≥3 mg/L) and HS was 6.599 (3.141~13.867) after adjusted for confounding factors (P < 0.001). Further stratification analysis by sex showed that men and women presented different associations of hs-CRP elevation and HS,and the ORs (95%CI) were 8.675 (3.206~23.469) and 3.836 (1.106~13.308) respectively. Conclusion:Our finding indicated that plasma hs-CRP elevation was significantly associated with increased risk of HS and the association was different between male and female.

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贾 锋,阮 舒,伏林山.超敏C反应蛋白与出血性脑卒中的1∶2匹配病例对照研究[J].南京医科大学学报(自然科学版),2013,(8):1099-1102

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  • 收稿日期:2012-12-27
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  • 在线发布日期: 2013-07-30
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