Objective:To explore the association of tumor necrosis factor receptor associted factor 1－complement 5(TRAF1－C5) rs3761847 polymorphism with rheumatoid arthritis (RA) susceptibility in East Asian. Methods:We searched all the publications about the association between TRAF1－C5 polymorphism and RA in East Asian population from PubMed,EMBase,SinoMed,CNKI and Wanfang. Meta－analysis was performed for A allele versus G allele,genotypes AA versus GG,GA versus GG,AA versus GG + GA and GA + AA versus GG using the Stata 10.0 software. OR with the association was obtained from the meta－analysis. Then heterogeneity and stratified analysis were conducted in the study. Results:A total of five eligible studies with 7 438 cases and 5 593 controls were included in this meta－analysis. No significant association was found between TRAF1－C5 polymorphism and RA in East Asian population. However,there is heterogeneity (I2 > 50%),then stratified analysis is used. When analyses were limited to country homogeneous population,significant association was found in Chinese and Japanese population,but not found in South Korea population. Conclusion:This meta－analysis demonstrates significant association between TRAF1－C5 polymorphism and RA in Chinese and Japanese population. More multi－center,large sample,homogeneity case－control studies are still needed to explore the association of TRAF1－C5 polymorphism with RA susceptibility in East Asian.