文章摘要
丁清清,管 蔚,丁永斌,梁 辉,薛绮萍,陈 琪.结直肠癌中FcγRⅡ和VEGF-A的表达与临床意义[J].南京医科大学学报,2014,(2):179~182
结直肠癌中FcγRⅡ和VEGF-A的表达与临床意义
Expression and clinical significance of FcγRⅡ and VEGF-A in colorectal cancer
投稿时间:2013-10-19  
DOI:10.7655/NYDXBNS20140211
中文关键词: 结直肠癌  FcγRII  VEGF-A
英文关键词: colorectal cancer  FcγRⅡ  VEGF-A
基金项目:江苏省六大人才高峰资助项目(WSW-027);江苏省高校自然科学研究资助项目(13KJB320012);国家自然科学基金重点项目(81230070)
作者单位
丁清清 南京医科大学第一附属医院老年医学科,江苏 南京 210029 
管 蔚 南京医科大学第一附属医院普外科,江苏 南京 210029 
丁永斌 南京医科大学第一附属医院普外科,江苏 南京 210029 
梁 辉 南京医科大学第一附属医院普外科,江苏 南京 210029 
薛绮萍 南京医科大学第一附属医院老年医学科,江苏 南京 210029 
陈 琪 南京医科大学病理生理学系,江苏 南京 210029 
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中文摘要:
      目的:探讨免疫球蛋白G Fc段低亲和力受体Ⅱ (FcγRⅡ) 和表皮生长因子A (VEGF-A)在结直肠癌,发生发展中的作用机制?方法:采用实时荧光定量PCR法,检测FcγRⅡ?VEGF-A基因在56例大肠癌组织和相应切缘正常组织中的表达,分析FcγRⅡ和VEGF-A与患者临床病理特征之间的关系,以及FcγRⅡ与VEGF-A的相关性?结果:FcγRⅡ基因表达在大肠癌组织中较正常组织低,其表达与大肠癌患者的浸润深度和TNM分期相关(均P < 0.05)?VEGF-A基因表达在大肠癌组织中较正常组织高,其表达与大肠癌患者的年龄?肿瘤大小?浸润深度和TNM分期相关(均P < 0.05)?肠癌患者FcγRⅡ基因的表达与VEGF-A呈负相关(r = -0.104, P = 0.002)?结论:FcγRⅡ基因与肠癌的侵袭转移等密切相关,其高表达提示较好的预后,推测可能是通过调控VEGF-A的表达而发挥作用?FcγRⅡ基因有望成为肿瘤免疫治疗的新途径?
英文摘要:
      Objective:To investigate the expression of FcγRⅡFc fragment of IgG,low affinity IIa,receptor(FcγRⅡ) and vascular endothelial growth factor A(VEGF-A) in colorectal cancer and analyze their association,and consequantly explore the mechanism of FcγRⅡin colorectal cancer. Methods:Expression of FcγRⅡand VEGF-A and their association with clinicopathological features were determined using real time polymerase chain reaction(RT-PCR) in 56 cases of colorectal cancer patients. The distribution of the clinicalpathologic and the expression of VEGF-A and FcγRⅡwere analyzed using Fisher’s exact test and the Chi-squared test. Spearman’s rank correlation was used to analyze the correlation between FcγRⅡand VEGF-A expression. Results:FcγRⅡmRNA expression in colorectal cancer tissues was significantly lower than that in matched adjacent normal tissues. FcγRII mRNA expression was significantly related to the patients’ infiltration depth and clinical stage(P < 0.05). VEGF-A mRNA expression in colorectal cancer tissues was significantly higher than that in matched adjacent normal tissues. VEGF-A mRNA expression was significantly related to the patients’ age,tumor size,infiltration depth and clinical stage(P < 0.05). In colorectal carcinoma, FcγRⅡand VEGF-A mRNA expression was significantly negatively correlated (r = -0.104, P = 0.002). Conclusion:The expression of VEGF-A and FcγRⅡwas associated with the clinical features of colorectal cancer. Expression of FcγRII was negatively correlated with VEGF-A. This study indicates that FcγRⅡand VEGF-A expression is related to the tumor invasion and metastasis. FcγRⅡ may become a new cancer immunotherapy target.
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