文章摘要
陈梦婕,董伟达,王美林,林 丹,陆美萍,张正东,徐洁洁.IL-13基因多态性与喉癌遗传易感性的关联研究[J].南京医科大学学报,2014,(5):574~579
IL-13基因多态性与喉癌遗传易感性的关联研究
Association of genetic polymorphisms of IL-13 and risk of laryngeal cancer
投稿时间:2013-10-27  
DOI:10.7655/NYDXBNS20140508
中文关键词: 喉癌  多态性,单核苷酸  白细胞介素13(IL-13),基因  易感性
英文关键词: laryngeal cancer  polymorphism,single nucleotide  interleukin-13,gene  susceptibility
基金项目:江苏省“科教兴卫工程”医学重点学科研究基金(XK200719);江苏高校优势学科建设工程资助项目(PAPD2010-2013);江苏省卫生厅科研项目(Z201202)
作者单位
陈梦婕 南京医科大学第一附属医院耳鼻咽喉科,江苏 南京 210029 
董伟达 南京医科大学第一附属医院耳鼻咽喉科,江苏 南京 210029 
王美林 南京医科大学公共卫生学院,江苏 南京 211166 
林 丹 南京医科大学第一附属医院耳鼻咽喉科,江苏 南京 210029 
陆美萍 南京医科大学第一附属医院耳鼻咽喉科,江苏 南京 210029 
张正东 南京医科大学公共卫生学院,江苏 南京 211166 
徐洁洁 南京医科大学第一附属医院耳鼻咽喉科,江苏 南京 210029 
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中文摘要:
      目的:探讨白细胞介素-13(interleukin-13,IL-13)基因单核苷酸多态性(single-nucleotide polymorphism,SNP)与喉癌遗传易感性的关系?方法:通过病例-对照研究设计,以111例经病理确诊的喉癌患者和340例健康对照者为研究对象,选取IL-13基因3’-UTR的SNP位点rs1295685,采用TaqMan探针方法进行多态性检测,应用Logistic回归计算OR值及其95%CI,比较不同基因型与喉癌发病风险的关联?结果:病例组与对照组中rs1295685(IL-13C870T)位点基因型分布存在统计学差异,在调整年龄?吸烟?饮酒及肿瘤家族史因素后发现,与CC基因型相比,携带TT/CT基因型者喉癌发病风险显著增高(调整OR值为2.00,95%CI为1.23~3.27,P值为0.005)?与CC基因型相比,携带TT/CT基因型在年龄≤62岁?吸烟?饮酒?无肿瘤家族史各亚组中表现出更高的喉癌患病风险(OR = 2.72,95%CI:1.40~5.28; OR = 2.07,95%CI:1.19~3.58;OR = 1.96,95%CI:1.03~3.73;OR = 2.01,95%CI:1.18~3.41)?吸烟?饮酒均与TT/CT基因型存在协同作用(OR = 6.48,95%CI:2.77~15.14和OR = 7.35,95%CI:3.15~17.12)?而基因型分布在肿瘤分期?分级中未见显著差异?结论:IL-13基因rs1295685位点的单核苷酸多态性与喉癌遗传易感性有关联?
英文摘要:
      Objective:To investigate the association between single nucleotide polymorphisms of IL-13 gene and susceptibility to laryngeal cancer in a Chinese population. Methods:A case-control study included 111 laryngeal squamous cell carcinoma (LSCC) patients and 340 cancer-free controls. Genotyping of the polymorphisms located at the 3’untranslated region (UTR) of IL-13 gene was conducted using MGB TaqMan Probe Assay. Logistic regression model was used to assess the contribution of genetic effects on the development of laryngeal cancer. Results:Individuals with IL-13 rs1295685 TT/CT genotypes had a increased risk of laryngeal cancer (adjusted OR = 2.00,95%CI:1.23~3.27,P = 0.005). Particularly among younger patients (OR = 2.72 and 95%CI:1.40~5.28),smokers (OR = 2.07 and 95%CI:1.19~3.58),drinkers (OR = 1.96 and 95%CI:1.03~3.73) and those without a family history of cancer (OR = 2.01 and 95%CI:1.18~3.41). Furthermore,compared with those,who were both nonsmokers and CC carriers,significantly increased risk was observed in those,who were smokers and TT/CT carriers (OR = 6.48 and 95%CI:2.77~15.14). The similar situation was found in drinkers(OR = 7.35 and 95%CI:3.15~17.12). No significant relationship was observed between rs1295685 polymorphism and progression of laryngeal cancer. Conclusion:The polymorphisms of IL-13 gene may play an important role in the etiology of laryngeal cancer.
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