文章摘要
袁春平,李中武,张 玮,王东苗,程 杰,杨建荣.LDH5在舌鳞状细胞癌中的表达及其临床意义[J].南京医科大学学报,2014,(7):926~929
LDH5在舌鳞状细胞癌中的表达及其临床意义
The expression and clinical significance of LDH5 in tongue squamous cell carcinoma
投稿时间:2013-10-29  
DOI:10.7655/NYDXBNS20140714
中文关键词: 舌鳞状细胞癌  LDH5基因  有氧糖酵解  免疫组织化学染色
英文关键词: tongue squamous cell carcinoma  LDH5  aerobic glycolysis  immunohistochemistry
基金项目:国家自然科学基金(81100737),江苏省自然科学基金(BK2011762),教育部高等学校博士学科点专项科研基金(20113234120003)
作者单位
袁春平 南京医科大学口腔医学研究所,南京 江苏 210029 
李中武 南京医科大学口腔医学研究所,南京 江苏 210030 
张 玮 南京医科大学附属口腔医院口腔病理科,南京 江苏 210029 
王东苗 南京医科大学口腔医学研究所,南京 江苏 210032 
程 杰 南京医科大学口腔医学研究所,南京 江苏 210033 
杨建荣 南京医科大学口腔医学研究所,南京 江苏 210034 
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中文摘要:
      目的:探讨LDH5蛋白在舌鳞状细胞癌组织中的表达特点,及其与临床病理和患者生存预后的关系?方法:应用免疫组织化学染色法检测LDH5蛋白在63例舌癌组织标本和16例正常舌黏膜组织标本中的表达?结合患者临床病理资料和随访资料,应用SPSS17.0软件分析LDH5的表达与相关临床病理参数(Fisher精确概率法)以及患者总生存率之间的关系(Kaplan-Meier法)?结果:LDH5在部分舌鳞癌组织中呈高表达(33/63,52.38%),与其在正常舌黏膜组织的表达水平相比有显著统计学差异(P < 0.01)?LDH5蛋白表达水平与肿瘤大小?颈淋巴结转移?临床分期具有相关性(P < 0.05),而与患者的性别?年龄?病理分级?局部浸润等无相关性(P > 0.05)?Kaplan-Meier 法分析患者总体生存情况结果显示:LDH5高表达组患者的总体生存率明显低于LDH5低表达组患者(P = 0.006,Log-rank检验)?结论:LDH5在部分舌鳞状细胞癌组织中呈异常高表达,其表达水平与肿瘤的病理学特征及患者预后具有相关性?
英文摘要:
      Objective:To investigate the characteristics of LDH5 expression in tongue squamous cell carcinoma (TSCC) and its relationship with clinicopathological parameters and survival. Methods:The LDH5 protein expression in 63 cases of TSCC and 16 cases of normal tongue mucosa were examined by immunohistochemistry. Based on these patients’ information and their follow-up data,the correlation of LDH5 expression with patients’ clinicopathological characteristics and overall survival were further evaluated by SPSS17.0 software using Fisher exact test and Kaplan-Meier method,respectively. Results:The LDH5 expression in TSCC (33/63,52.38%) was much higher than that in normal tongue (P < 0.001). LDH5 over-expression was found to be associated with tumor size,cervical lymph node metastasis and clinical stages (P < 0.05),but not with gender,age,local invasion and pathological grades(P > 0.05). The overall survival rate in patients with high LDH5 expression was significantly lower than that in patients with low expression as estimated by Kaplan-Meier and Log-rank test(P = 0.006). Conclusion:LDH5 is aberrantly over-expressed in a significant fraction of TSCC patients. Its upregulation is associated with multiple clinicopathological features and patients’ prognosis.
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