文章摘要
夏 曦.血清miR-126在先天性心脏病患儿中的变化及临床意义[J].南京医科大学学报,2014,(7):965~967
血清miR-126在先天性心脏病患儿中的变化及临床意义
The changes of serum miR-126 in children with congenital heart disease and its clinical significance
投稿时间:2013-11-05  
DOI:10.7655/NYDXBNS20140722
中文关键词: 先天性心脏病  血清小RNA  miR-126
英文关键词: congenital heart disease  serum microRNA  miR-126
基金项目:
作者单位
夏 曦 南京医科大学附属南京儿童医院心内科,江苏 南京 210008 
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中文摘要:
      目的:探讨血清miR-126的水平变化在先天性心脏病(CHD)患儿中的检测价值?方法:选取2013年1~6月本院心内科CHD患儿54例,其中左向右分流型先心病组(非发绀组)40例(心衰组20例,无心衰组20例),右向左分流型先心病组(发绀组)14例,正常对照组20例?测定各组患儿血清中miR-126的水平,分析新生儿CHD血清miR-126与心力衰竭的相关性?结果:相比正常对照组,非发绀组和发绀组患儿血清miR-126表达水平显著降低(P < 0.05,P < 0.01),且发绀组患儿血清miR-126表达水平低于非发绀组(P < 0.01)?在非发绀组患儿中,心衰组miR-126表达水平低于无心衰组(P < 0.001)?结论:CHD患儿血清miR-126显著降低,且病情越重降低越明显,提示miR-126可能参与了CHD的病变过程,可作为预测CHD风险的独立评价指标?
英文摘要:
      Objective:To determine miR-126 serum levels in children with congenital heart disease(CHD). Methods:A total of 54 children with CHD who received treatment in Department of Cardiology from January 2013 to June 2013 were enrolled. There were 40 children with left-right shunt acyanotic CHD(the ACHD group),including 15 children with heart failure(ACHDⅠ)and 25 children without heart failure(ACHDⅡ). There were 14 children with right-left shunt cyanotic CHD(the CCHD group)and 20 healthy children(the control group). The serum miR-126 expression level was measured to analyze the correlation between the serum miR-126 of neonates with CHD and heart failure. Results:Compared with normal controls,the expression levels of miR-126 in the ACHD group and the CCHD group were significantly down-regulated(P < 0.001). The expression levels of miR-126 in the CCHD group were significantly lower than those in the ACHD group(P < 0.05 and P < 0.001,respectively). MiR-126 expression levels were lower in the ACHDⅠ group those in the ACHDⅡ group(P < 0.001). Conclusion:The expression levels of serum miR-126 in children with CHD were significantly decreased and correlated with the severity and degree of impaired cardiac function,indicating that miR-126 may be involved in the pathological process of CHD,and it may serve as an independent evaluation indicator for the diagnosis of CHD.
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