恢复期老年期抑郁症患者认知功能与日常生活能力相关性研究
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国家临床重点专科建设项目(卫生部医政司2011-873);江苏省医学重点学科(江苏省卫生厅2011-12);国家自然科学基金重大研究计划培育项目(91132727);南京市医学科技发展项目(YKK13126)


Correlation between cognitive function and activities of daily living in remitted geriatric depression
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    目的:研究恢复期老年期抑郁症(remitted geriatric depression,RGD) 患者认知功能和日常生活能力以及两者的相关性-方法:入组RGD患者51例,正常对照组52例,主要以Mattis痴呆评定量表(Mattis dementia rating scale,MDRS)和日常生活能力评估量表(activities of daily living scal,ADL)评估受试者认知功能及日常生活能力-结果:RGD患者认知功能明显低于对照组,且其认知功能与汉密尔顿抑郁量表(Hamilton depression rating scale,HAMD)得分和是否服用抗抑郁药无相关性;RGD患者ADL评分显著低于正常对照组;MDRS量表起始/保持得分与ADL评分存在显著负相关-结论:认知功能障碍可能作为RGD患者内源性损害持续存在,并影响患者日常生活能力-

    Abstract:

    Objective:To study cognitive function and activities of daily living (ADL) in patients with remitted geriatric depression (RGD) and to determine their relationship. Methods:Fifty-one patients with GRD and 52 normal control subjects were recruited. Their cognitive function and ADL were mainly examined by Mattis dementia rating scale (MDRS) and ADL scale. Results:Compared with control subjects,patients with RGD showed poorer cognitive function,which was not associated with Hamilton depression rating scale for depression (HAMD) scores and antidepressant treatment. ADL score of RGD patients was significantly lower than that of normal control subjects. The score of initiation/perseveration subscales of MDRS was significantly negative correlated with ADL scores. Conclusion:Cognitive impairments might be persisted as endogenous damages of RGD,which may affect ADL.

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张向荣,梅 刚,廖文象,郑丽梅,李海林.恢复期老年期抑郁症患者认知功能与日常生活能力相关性研究[J].南京医科大学学报(自然科学版),2014,(11):1545-1549

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  • 收稿日期:2014-01-20
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  • 在线发布日期: 2014-11-21
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