Objective:To study the expressions of tumor necrosis factor alpha induced protein 3 (TNFAIP3) and manganese superoxide dismutase (Mn-SOD) mRNA in radiotherapeutic nasopharyngeal carcinoma,as well as their significances. Methods:In situ hybridization detections were performed to detect the expressions of TNFAIP3 and Mn-SOD in radiotherapeutic nasopharyngeal carcinoma. Results:In radiosensitive and radioresistant nasopharyngeal carcinoma,the moderately and strongly positive TNFAIP3 mRNA expression rates were 15.00% and 45.00%,respectively;the moderately and strongly positive Mn-SOD mRNA expression rates were 55.00% and 40.00%,respectively,and there were statistical significances (both P < 0.05). In radioresistant nasopharyngeal carcinoma,the moderately and strongly positive TNFAIP3 mRNA expression was positively correlated with TNM stage. In III-IV stage and Ⅰ~Ⅱ stage,the moderately and strongly positive expression rates were 48.28% and 36.36%,respectively. The moderately and strongly positive Mn-SOD mRNA expression was positively correlated with T stage. In stage of T3~T4 and T1~T2,the moderately and strongly positive expression rates were 63.16% and 19.05%,respectively. In distant metastasis and no distant metastasis,the moderately and strongly positive TNFAIP3 mRNA expression rates were 81.81% and 31.03%,respectively;the moderately and strongly positive Mn-SOD mRNA expression rates were 81.82% and 24.14%,respectively,and the differences had statistical significance (both P < 0.05). Conclusion:TNFAIP3 gene is correlated with the occurrence and development of radioresistant nasopharyngeal carcinoma. Mn-SOD gene can increase the radiosensitivity of nasopharyngeal carcinoma and the anti-oxidative effect of radioresistant nasopharyngeal carcinoma.