文章摘要
杜 强,崔 进,蔡健康,朱成华,黄 茂,查王健.百令胶囊对中重度慢性阻塞性肺病患者肺功能、气道炎症以及氧化应激的影响[J].南京医科大学学报,2015,(1):58~61
百令胶囊对中重度慢性阻塞性肺病患者肺功能、气道炎症以及氧化应激的影响
Effects of Bailing capsule on pulmonary function,airway inflammation and oxidative stress in patients with moderate to severe chronic obstructive pulmonary disease
投稿时间:2014-05-23  
DOI:10.7655/NYDXBNS20150112
中文关键词: 慢性阻塞性肺疾病  信必可都保  百令胶囊  氧化应激
英文关键词: COPD  symbicort turbuhaler  Bailing capsule  oxidative stress
基金项目:江苏省卫生厅面上科研项目(H201205)
作者单位
杜 强 南京医科大学第二附属医院呼吸科,江苏 南京 210011 
崔 进 南京医科大学第二附属医院呼吸科,江苏 南京 210011 
蔡健康 南京医科大学第二附属医院呼吸科,江苏 南京 210011 
朱成华 南京医科大学第二附属医院呼吸科,江苏 南京 210011 
黄 茂 南京医科大学第一附属医院呼吸科,江苏 南京 210029 
查王健 南京医科大学第一附属医院呼吸科,江苏 南京 210029 
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中文摘要:
      目的:评价百令胶囊对中重度稳定期慢性阻塞性肺疾病(COPD)患者肺功能?气道炎症以及氧化应激的影响。方法:60例中重度COPD患者随机分成对照组和治疗组,每组30例。对照组常规使用布地奈德/福莫特罗复方干粉吸入剂(信必可都保)吸入,治疗组使用信必可都保吸入联合百令胶囊口服,在治疗前和治疗后第24周分别进肺功能检查?诱导痰中炎性细胞分类检测以及血清超氧化物歧化酶(SOD)?丙二醛(MDA)和总抗氧化能力(TAOC)的检测。结果:对照组和治疗组治疗后第1秒用力呼气容积(FEV1)?FEV1占预计值百分比(FEV1%)以及FEV1占用力肺活量百分比(FEV1/FVC)均显著改善(P均 < 0.001),且治疗组疗效优于对照组(P均 < 0.05);两组治疗后诱导痰中中性粒细胞比例下降,巨噬细胞比例升高,与治疗前相比有统计学意义(P均 < 0.001),且治疗组疗效优于对照组(P均 < 0.001);对照组和治疗组治疗后血清SOD和TAOC升高?MDA下降,与治疗前相比有统计学意义(P均 < 0.05),且治疗组疗效优于对照组(P均 < 0.001)。结论:百令胶囊可改善COPD患者肺功能,减轻气道炎性反应,抑制机体氧化应激。
英文摘要:
      Objective: To observe the clinical effects of bailing capsule on pulmonary function, airway inflammation and oxidative stress in patients with moderate to severe chronic obstructive pulmonary disease (COPD). Methods: Sixty patients with moderate to severe COPD were randomly divided into two groups: the control group and the treatment group. Every group contained 30 patients. The control group was treated with symbicort turbuhaler,and the treatment group was treated with symbicort turbuhaler plus bailing capsule. The pulmonary function and the inflammatory cells classification in induced sputum were measured before and after treatment (24 weeks). Serum superoxide dismutase(SOD), malondialdehyde (MDA) and total antioxidant capacity (TAOC) in serum were detected in the two groups. Results: Forced expiratory volume in 1 second (FEV1), FEV1% and FEV1/forced expiratory volume (FEV1/FVC%) were significantly improved after treatment in the control group and the treatment group compared to pretreatment (all P < 0.001), and all were better in the treatment group than that of the control group (all P< 0.05); The percentage of neutrophils was decreased and the percentage of macrophages was increased in induced sputum after treatment in both groups compared with pretreatment (all P < 0.001), and the changes are more significat in the treatment group compared to the control group (all P < 0.001); The levels of SOD and TAOC were enhanced, and level of MDA was reduced after treatment in the control group and treatment group compared to pretreatment (all P < 0.05), and the changes are more remarkable in. the treatment group compared to the control group (all P < 0.001). Conclusion:Bailing capsule could improve pulmonary function, reduce airway inflammation and inhibit oxidative stress in COPD patients.
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