Objective:To investigate whether I198T and A379V polymorphisms in lipoprotein-associated phospholipase A2(Lp-PLA2)correlate with severity and stability of coronary atherosclerosis. Methods:V279F and A379V polymorphisms in Lp-PLA2 gene of 268 patients with coronary atherosclerosis and 113 controls without coronary atherosclerosis were genotyped by DNA sequencing instrument and analyzed by statistical methods. Results:Stratified by Gensini score and clinical types,no significant associations were observed between subgroups and the controls in I198T and V279F genotypes and allele frequencies. As for subgroups stratified by numbers of diseased coronary branches,only subjects with one diseased coronary branches carried higher frequencies of genotype IT+TT,VF+FF and F allele as compared to the controls. No associations were observed between patients with multi-vessel lesions and controls in I198T and V279F. In the further analysis of risk factors,blood fat levels and proportions of diabetes and hypertension patients in subjects carrying IT+TT and VF+VV genotypes showed no difference with II and VV genotypes. Conclusion:No associations existed between I198T and V279F polymorphisms in Lp-PLA2 and the severity and stability of coronary atherosclerosis.