文章摘要
魏义圆,郭万华.中期18F-FDG PET/CT在弥漫大B细胞淋巴瘤疗效评价中的价值分析[J].南京医科大学学报,2015,(6):891~894
中期18F-FDG PET/CT在弥漫大B细胞淋巴瘤疗效评价中的价值分析
The value of response assessment of interim 18F-FDG PET/CT in patients with diffuse large B-cell lymphoma
投稿时间:2014-07-15  
DOI:10.7655/NYDXBNS20150628
中文关键词: 弥漫大B细胞淋巴瘤  脱氧葡萄糖  PET/CT
英文关键词: diffuse large B-cell lymphoma  deoxyglucose  PET/CT
基金项目:国家自然科学基金(81171363)
作者单位
魏义圆 南京医科大学鼓楼临床医学院核医学科,江苏 南京 210008 
郭万华 南京医科大学鼓楼临床医学院核医学科,江苏 南京 210008 
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中文摘要:
      目的:探讨中期18F标记的脱氧葡萄糖正电子发射计算机断层显像(fluorie-18fluorodeoxyglucose positron emission tomography,18F-FDG PET/CT)在弥漫大B细胞淋巴瘤(diffuse large B-cell lymphoma,DLBCL)疗效评价的临床价值。方法:32例初诊并经病理证实的DLBCL,化疗前后均行18F-FDG PET/CT检查。参照2007年制定的恶性淋巴瘤疗效评价标准分组。统计分析采用独立样本t检验及二分类Logistic回归分析。结果:疗效佳(完全缓解和部分缓解)组和疗效不佳(疾病稳定和疾病进展)组的SUV4max(4疗程后化疗中期SUVmax)及ΔSUVmax(化疗前与化疗中期SUVmax差值)差异有统计学意义(P=0.021,P=0.028),与SUV0max(化疗前SUVmax)比较差异无统计学意义(P=0.494)。二分类Logistic回归分析示临床疗效的影响因素是SUV4max(OR=0.646)。结论:DLBCL患者治疗中期行18F-FDG PET/CT检查有助于化疗疗效的评估及后续治疗的指导。
英文摘要:
      Objective:To study the value of response assessment of interim fluorie-18fluorodeoxyglucose positron emission tomography (18F-FDG PET/CT) in patients with diffuse large B-cell lymphoma (DLBCL). Methods: A total of 32 DLBCL patients confirmed by pathology underwent 18F-FDG PET/CT before and after chemotherapy. According to the revised response criteria for malignant lymphoma 2007, the patients were divided into two groups. Independent samples t-test and binary logistic analysis were performed. Results: The differences of SUV4max (mid chemotherapy, after 4 chemotherapy cycles) and Δ SUVmax (the difference between SUV0max and SUV4max) between the CR+PR group and the SD+PD group were significant (P=0.021, P=0.028). Comparing the SUV0max (SUVmax before chemotherapy) of the CR+PR group and the SD+PD group, respectively, there were no statistical significances (P=0.494). Binary logistic analysis showed that SUV4max had a significant impact on the clinical effect (OR=0.646). Conclusion: The interim 18F-FDG PET/CT may be useful for the evaluation of chemotherapy and the guidance of subsequent treatment in DLBCL.
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