文章摘要
梅松涛.半乳糖凝集素3对慢性心力衰竭的诊断价值[J].南京医科大学学报,2015,(9):1238~1241
半乳糖凝集素3对慢性心力衰竭的诊断价值
The diagnostic value of galectin-3 in patients with chronic heart failure
投稿时间:2015-02-09  
DOI:10.7655/NYDXBNS20150911
中文关键词: 半乳糖凝集素3  慢性心力衰竭  预后  治疗
英文关键词: galectin-3  chronic heart failure  prognosis  treatment
基金项目:
作者单位
梅松涛 泸州医学院附属医院ICU,四川 泸州 646000 
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中文摘要:
      目的:考察半乳糖凝集素3(galectin-3)与慢性心力衰竭分级?治疗和预后之间的相关性。方法:选取泸州医学院附属医院2011年1月—2013年1月心血管内科就诊的患者140例,按心功能分级分为Ⅱ级组(47例)?Ⅲ级组(50例)?Ⅳ级组(43例),检测患者血galectin-3?超敏C反应蛋白(high sensitive C-reactive protein,hs-CRP)?N末端B型利钠肽原(N-terminal pro-brain natriuretic peptide,NT-proBNP)?左室舒张末期内径(left ventricular end-diastolic dimension,LVEDD)?左心室射血分数(ejection fraction,EF),比较治疗有效患者与无效患者galectin-3表达差异,分析galectin-3与预后之间的关系。结果:galectin-3与hs-CRP?NT-proBNP?LVEDD呈正相关(r=0.912,P < 0.05;r=0.772,P < 0.05;r=0.564,P < 0.05),与EF呈负相关(r=-0.612, P < 0.05);治疗有效组galectin-3显著高于无效组(t=3.81,P < 0.01);发生心脏事件组galectin-3显著高于未发生心脏事件组 (t=3.04,P < 0.01)。结论:galectin-3与慢性心力衰竭密切相关,可用于慢性心力衰竭的临床诊断。
英文摘要:
      Objective:To investigated the correlation between galectin 3 and chronic heart failure classification,treatment and prognosis. Methods:Total of 140 patients with chronic heart failure in our hospital were selected from January 2011 to January 2013,and divided into NYHA class Ⅱ group(47 cases),Ⅲ level group(50 cases),Ⅳ level group(43 cases). Serum galectin-3,high sensitive C-reactive protein(hs-CRP)and N-terminal pro-brain natriuretic peptide (NT-proBNP)were detected. Left ventricular end-diastolic dimension (LVEDD)and ejection fraction (EF)were also observed. Serum galectin-3 level was compared between patients with ineffective and effective treatment results. Correction between prognosis and galectin-3 was analyzed. Results:Galectin-3 was positively correlated with hs-CRP,lnNT-proBNP,LVEDD,respevtively (r=0.912,P < 0.05;r=0.772,P < 0.05;r=0.564,P < 0.05),and negative correlated with EF(r=-0.612,P < 0.05). Serum galectin-3 level of effective treatment group was significantly higher than that of ineffective treatment group(t = 3.81,P < 0.01). And serum galectin-3 level of group with cardiac events was significantly higher than that of group without cardiac events(t = 3.04,P < 0.01). Conclusion:Galectin-3 is closely related to chronic heart failure,and could be used for clinical diagnosis of chronic heart failure.
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