文章摘要
倪沂江,秦 辉,汤黎明.Rab27b在结直肠癌中的表达情况及临床意义[J].南京医科大学学报,2015,(10):1405~1408
Rab27b在结直肠癌中的表达情况及临床意义
Expression and clinical significance of Rab27b in colorectal cancer
投稿时间:2015-06-26  
DOI:10.7655/NYDXBNS20151015
中文关键词: 结直肠癌  Rab27b  预后
英文关键词: colorectal cancer  Rab27b  prognosis
基金项目:南京医科大学肿瘤中心招标课题(11ZLKF06)
作者单位
倪沂江 南京医科大学附属常州第二人民医院创伤外科,江苏 常州 213000 
秦 辉 南京医科大学附属常州第二人民医院重症监护科,江苏 常州 213000 
汤黎明 南京医科大学附属常州第二人民医院胃肠外科,江苏 常州 213000 
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中文摘要:
      目的:检测Rab27b在结直肠癌中的表达情况,并探讨Rab27b表达与结直肠癌中重要临床指标尤其是临床预后之间的关系。方法:在组织芯片上(80例肠癌标本及20例癌旁对照标本)进行免疫组化检测,使用Cox回归法及Kaplan-Meier生存分析法进行结直肠癌患者的预后分析。结果:免疫组化结果显示结直肠癌中的Rab27b表达明显高于癌旁对照组Rab27b的表达(P=0.041)。Rab27b的表达与结直肠癌患者的性别(P=0.012)?血清CEA水平(P=0.014)?远处转移(P=0.021)及TNM分期(P=0.013)有重要关联。生存分析显示Rab27b表达(P=0.021)与结直肠癌患者预后关系密切,Rab27b高表达提示预后不良。结论:Rab27b在结直肠癌组织中异常高表达,且Rab27b的表达与结直肠癌的数种恶性表型相关。Rab27b可作为结直肠癌患者预后的独立危险因素。
英文摘要:
      Objective: To detect the expression of Rab27b in human colorectal cancer (CRC) and investigate the relationship between Rab27b expression and clinical characteristics, especially the prognosis of CRC. Methods: Immunohistochemistry analysis by tissue microarrays (80 CRC samples and 20 tumor-adjacent tissue samples) was performed to characterize Rab27b expression in CRC. Cox regression and Kaplan-Meier survival analyses were carried out to evaluate the prognosis of CRC. Results: Immunohistochemistry analysis showed that the expression of Rab27b in CRC was significantly higher than that in normal tumor-adjacent tissues (P = 0.041). Moreover, the expression level of Rab27b protein in CRC was significantly related to gender (P = 0.012), serum CEA level (P = 0.014), distant metastasis (P = 0.021) and TNM stage (P = 0.013). COX multi-factor analysis showed that Rab27b expression (P = 0.021) could be recognized as an independent prognosis factor for CRC. Conclusion: Rab27b expression was abnormally highly expressed and correlated with malignant phenotypes of CRC. It may serve as a novel prognostic factor for CRC.
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