姜黄素对大鼠心肌梗死后炎症反应的抑制作用及其机制
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Role of curcumin in suppressing the inflammation after the myocardial infarction in rats and its underlying mechanisms
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    摘要:

    目的:探讨姜黄素对大鼠心肌梗死(myocardial infarction,MI)后炎症反应的抑制作用及相应机制。方法:采用Wistar 大鼠,通过结扎冠状动脉建立MI模型,观察姜黄素对于梗死后不同时间心肌组织中炎症反应和炎症因子表达的影响,探讨其相关的分子生物学机制。结果:与对照组比较,姜黄素的使用明显改善MI后28 d的心脏功能,并降低MI后梗死区1-7-14及28 d的炎症细胞浸润;进一步研究显示姜黄素降低了大鼠MI后不同时段肿瘤坏死因子α-白细胞介素1β和白细胞介素6的表达,并抑制NF-κB和JAK-1/SATA3信号通路的激活。结论:姜黄素可通过抑制MI后炎症相关信号通路的激活来减少梗死区炎症细胞的浸润和炎症因子的分泌,减缓炎症反应,从而起到改善血流动力学-减轻心室重构和维护心功能的保护作用。

    Abstract:

    Objective: To investigate the inhibitory effects of curcumin on the inflammation after myocardial infarction (MI) in rats and its underlying mechanisms. Methods: The Wistar rat MI models were established through the ligation of the left anterior descending coronary artery. Infiltration of inflammatory cells and the expression of related cytokines at different time points after MI were detected,and then we tried to uncover the underlying molecular mechanisms suppressing the inflammation by curcumin with Western blot. Results: Compared with the control group, the use of curcumin significantly improved cardiac function in 28 d after MI, and reduced the inflammatory cells infiltration of infarction area after MI 1 d, 7 d, 14 d and 28 d; further studies suggested that curcumin decreased inflammatory cytokines such as TNF-α, IL-1β and IL-6 in rats after MI at different times, and suppressed the activation of NF-κB and JAK-1/SATA3 signaling pathways. Conclusion: Curcumin can inhibit inflammation after MI by signaling pathways to reduce infiltration of inflammatory cells in infarct area and reduce the secretion of inflammatory cytokines, thus improve hemodynamics, reduce ventricular remodeling and maintain cardiac function.

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陈磊磊,王泽穆,陈 波,王连生,杨志健.姜黄素对大鼠心肌梗死后炎症反应的抑制作用及其机制[J].南京医科大学学报(自然科学版),2015,(11):1552-1556

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  • 收稿日期:2015-05-23
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  • 在线发布日期: 2015-11-30
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