文章摘要
蔡 赟,陈欢欢,王知笑,戎 荣,吴云松,崔 岱,蒋 琳,魏 玲,段 宇,杨 涛,刘晓云.Bethesda细胞病理报告系统在甲状腺细针穿刺中的应用[J].南京医科大学学报,2015,(12):1718~1721
Bethesda细胞病理报告系统在甲状腺细针穿刺中的应用
Application of Bethesda system for reporting cytology in thyroid fine needle aspiration
投稿时间:2015-08-13  
DOI:10.7655/NYDXBNS20151210
中文关键词: Bethesda细胞病理报告系统  甲状腺细针穿刺  细胞病理  甲状腺结节  甲状腺囊性变  慢性淋巴细胞性甲状腺炎  亚急性甲状腺炎
英文关键词: the Bethesda system for reporting thyroid cytology  fine-needle aspiration  cytopathology  thyroid nodules  capsula glandulae thyroideae  chronic lymphocytic thyroiditis  subacute thyroiditis
基金项目:国家自然科学基金(30971405,81270897);国家临床重点专科培育项目;江苏高校优势学科建设工程资助项目
作者单位
蔡 赟 南京医科大学第一附属医院内分泌科,江苏 南京 210029 
陈欢欢 南京医科大学第一附属医院内分泌科,江苏 南京 210029 
王知笑 南京医科大学第一附属医院内分泌科,江苏 南京 210029 
戎 荣 南京医科大学第一附属医院病理科,江苏 南京 210029 
吴云松 南京医科大学第一附属医院病理科,江苏 南京 210029 
崔 岱 南京医科大学第一附属医院内分泌科,江苏 南京 210029 
蒋 琳 南京医科大学第一附属医院内分泌科,江苏 南京 210029 
魏 玲 南京医科大学第一附属医院内分泌科,江苏 南京 210029 
段 宇 南京医科大学第一附属医院内分泌科,江苏 南京 210029 
杨 涛 南京医科大学第一附属医院内分泌科,江苏 南京 210029 
刘晓云 南京医科大学第一附属医院内分泌科,江苏 南京 210029 
摘要点击次数: 2425
全文下载次数: 1026
中文摘要:
      目的:将Bethesda细胞病理报告系统(TBS)应用于甲状腺细针穿刺(FNA)细胞病理读片,提高 FNA细胞病理诊断水平。方法:收集1 705份FNA细胞病理样本,同时对比分析其中66例接受外科手术的组织病理样本。结果:1 705份中病理片归为“无诊断价值”(N)?“良性”(B)?“不确定价值的不典型增生”(AUS)?“滤泡性肿瘤”(FN)?“怀疑恶性”(S)和“恶性”(M)的分别有295(17.30%)?1 291(75.72%)?30(1.76%)?19(1.11%)?36(2.11%)和34(1.99%)例。总体阳性细胞率82.70%。对66例同时接受FNA和手术的患者细胞和组织病理对比分析得出,前2类总体恶性可能性仅为11.11%,而后4类总体恶性可能性为63.33%,较前者显著升高(P < 0.01)。FNA对恶性或癌前病变诊断的敏感性为82.61%,特异性为74.42%,阳性预测值为63.33%,阴性预测值为88.89%,假阳性率为25.58%,假阴性率为17.39%。结论:TBS类别中AUS?FN?S和M类恶性风险较高,对于指导临床实践有重要价值。
英文摘要:
      Objective:Application of the Bethesda system (TBS)for reporting thyroid cytology in fine needle aspiration(FNA)to improve the capability of cytopathological diagnosis. Methods:Totally 1 705 FNA cytopathological samples were analyzed from May 2011 to Jun 2012. Sixty-six histological pathological samples from these patients were analyzed in the meantime. Results:According to TBS,1 705 FNA cytopathological samples were classified into six categories with 295(17.30%)as nondiagnostic(N),1 291(75.72%)as benign(B),30(1.76%)as atypia of undetermined significance(AUS),19(1.11%)as follicular neoplasm(FN),36(2.11%)as suspicious(S)and 34(1.99%)as malignant(M). Total positive cell rate was 82.70%. It was concluded from the comparison of histopathological and cytopathological slides of 66 patients that the overall occurrence rate of malignancy was 11.11% in former two groups,which was significantly lower than that (63.33%) in latter four groups (P < 0.01). The sensitivity,specificity,positive predictive value,negative predictive value,false positive rate and false negative rate for FNA in differentiation of benign and malignant lesions were calculated as 82.61%,74.42%,63.33%,88.89%,25.58% and 17.39%, respectively. Conclusion:TBS showed great importance in differentiation of benign and malignant thyroid lesions,with high probability of malignancy in AUS,FN,S and M groups.
查看全文   查看/发表评论  下载PDF阅读器