Objective:To observe the rapid plasma reagin change in pregnant syphilis patients treated with combination of ceftriaxone sodium and bicillin. Methods:Retrospective analysis was performed to 65 cases ivas performed the petients to diagnosis and treatment of pregnant syphilis patients in our department,according to the different treatment methods, the patints were divided into the treatment group of 33 cases,32 cases in the control group. The treatment group was treated with ceftriaxone sodium combined with benzathine penicillin treatment,and the control group received benzathine penicillin therapy,clinical effect and the pregnancy outcome after treatment were compared between two groups. Results:The cases of RPR negative conversion in the treatment group were 26,and the rate of RPR negative conversion was 78.79%,while that of the control group were 17 (53.13%),showing significant differences between two groups (P < 0.05). Patients in the two groups after treatment didn’t give birth to baby with congenital syphilis,stillbirth,low birth weight fetal and neonatal death,and in the control group after treatment 1 cases of premature delivery was reported. No difference showed in pregnancy outcome. Conclusion:Combined usages of cefiriaxone sodium and bicillin for treatment of pregnant syphilis patients with rapid plasma reagin high titer can apparently shorten the time of RPR negative conversion.