Objective:The vitamin D receptor(VDR)gene polymorphisms have been suggested to be involved in the development of type 1 diabetes(T1D). However,the results to date have been inconclusive. We performed a meta-analysis to examine the associations. Methods:Literature was retrieved from PubMed,Web of Science and Chinese databases WanFang. Pooled odds ratios(ORs)with 95% confidence intervals (CIs) were calculated using a random effect model. Results:The results indicated that BsmⅠ and ApaⅠ were associated with an increased risk of T1D (B vs b:OR=1.10,95%CI:1.04~1.18,P=0.003,AA vs aa:OR=1.24,95%CI:1.05~1.46,P=0.012,),while the FokⅠ and TaqⅠ polymorphisms were not. In the subgroup analysis by ethnicity and area,the increase risk of T1D remain in the East Asian and Latino subgroup for the BsmⅠ polymorphism(B vs b:OR=1.52,95%CI:1.33~1.74,P < 0.001 for East Asian;OR 1.51,95%CI:1.25~1.82,P < 0.001 for Latino),East Asian subgroup for the ApaⅠ polymorphism(AA vs aa:OR 1.99,95%CI:1.20~3.29,P=0.007). Whereas no significant association was found in other population. Conclusion:Our meta-analysis suggests that the BsmⅠ and ApaⅠ polymorphism may be a risk factor for susceptibility to T1D in Asians. Moreover,BsmⅠ polymorphism may be a risk factor in Latinos. However,the FokⅠ and TaqⅠ polymorphisms are unlikely to be associated with increased T1D risk in the populations investigated.