文章摘要
龚燕梅,沈祥波.阻塞性睡眠呼吸暂停低通气综合征患者血清PCSK9及LDL-C水平变化及其对脑梗死的预测作用[J].南京医科大学学报,2016,(4):452~455
阻塞性睡眠呼吸暂停低通气综合征患者血清PCSK9及LDL-C水平变化及其对脑梗死的预测作用
Serum PCSK9 and LDL-C level changes in OSAHS and the prediction for OSAHS combined with cerebral infarction
投稿时间:2015-07-19  
DOI:10.7655/NYDXBNS20160415
中文关键词: 阻塞性睡眠呼吸暂停低通气综合征  脑梗死  低密度脂蛋白胆固醇  前蛋白转化酶枯草溶菌素-9
英文关键词: obstructive sleep apnea-hypopnea syndrome  cerebral infarction  low density lipoprotein cholesterol  proprotein convertase subtilisin/kexin type 9
基金项目:
作者单位
龚燕梅 宁波市第七医院神经内科,浙江 宁波 315200 
沈祥波 宁波市北仑区人民医院心内科,浙江 宁波 315800 
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中文摘要:
      目的:检测阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血清前蛋白转化酶枯草溶菌素-9(PCSK9)及低密度脂蛋白胆固醇(LDL-C)水平变化及其对OSAHS并发脑梗死的预测作用。方法:从本院2010年以来门诊及住院患者中随机抽取OSAHS合并脑梗死患者27例(A组),单纯性OSAHS患者30例(B组)以及健康体检者30例(C组),用ELISA法检测3组患者血清中PCSK9的水平,全自动分析仪检测LDL-C水平。比较3组患者血清PCSK9及LDL-C水平变化,同时比较A?B两组患者睡眠呼吸监测指标,并对其血清PCSK9及LDL-C与睡眠呼吸监测指标进行直线相关分析。结果:①A组患者血清PCSK9?LDL-C水平高于B?C组(P < 0.05);②睡眠呼吸监测指标显示,A组患者病情较B组严重(P < 0.05);③A?B两组患者血清PCSK9?LDL-C水平分别与其睡眠呼吸暂停低通气指数(AHI)?睡眠呼吸障碍事件占总睡眠时间百分比?血氧饱和度<90%时间占总睡眠时间百分比呈正相关(P < 0.05);与最低血氧饱和度及平均最低血氧饱和度呈负相关(P < 0.05)。结论:OSAHS患者血清PCSK9及LDL-C升高幅度与其严重程度密切相关,并可作为OSAHS合并脑梗死的预测指标。
英文摘要:
      Objective:To investigate serum PCSK9 and LDL-C level changes in obstructive sleep apnea-hypopnea syndrome(OSAHS),and assess the prediction for OSAHS combined with cerebral infarction. Methods:87 patients were admitted to this trial in our hospital,and they were divided into three groups:OSAHS combined with cerebral infarction group (group A),isolated OSAHS group(group B) and control group(group C). Serum PCSK9 concentration was measured by ELISA and LDL-C level were measured by automatic biochemical analyzer,and then they were applied SNK test to perform statistical analysis. Polysomnography(PSG) results of group A and group B were also compared. Furthermore,correlational analyses were conducted between the two factors and PSG results in OSAHS associate with cerebral infarction and isolated OSAHS patients respectively. Results:①Serum PCSK9 and LDL-C levels were higher in group A than those in group B and group C (P < 0.05). ②PSG results showed that patients in group A were more severe than that in group B (P < 0.05). ③Serum PCSK9 and LDL-C levels in OSAHS associate with cerebral infarction and isolated OSAHS patients were correlated positively with apnea hypopnea index (AHI),percentage of sleep time during apnea-hypopnea and percentage of sleep time below 90% oxygen saturation(SaO2 < 90%) respectively(P < 0.05),and those were correlated negatively with the lowest SaO2 and the average lowest SaO2 respectively (P < 0.05). Conclusion:The increasing amplitude of serum PCSK9 and LDL-C levels is interrelated with the degree of OSAHS,and can be seem as clinical predictors of OSAHS combined with cerebral infarction.
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