血清核仁素检测在结肠癌中的临床应用
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国家自然科学基金(21475063)


Expression of serum nucleolin and its clinical relevance in colorectal cancer
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    摘要:

    目的:探讨核仁素(nucleolin)在结肠癌患者血清中的水平与临床意义-方法:用酶联免疫吸附实验(ELISA)法检测172例结肠癌患者-24例直肠癌患者和80例健康体检者血清中核仁素含量,并分析血清核仁素水平与结肠癌患者临床病理特征之间的关系-结果:结肠癌患者血清中核仁素含量为(228.9 ± 212.4)pg/mL,直肠癌患者为(115.1 ± 34.5)pg/mL,健康对照组为(101.13 ± 32.4)pg/mL-结肠癌患者血清核仁素水平明显高于健康对照组(P < 0.001),直肠癌患者与健康对照组间差异无统计学意义(P > 0.05)-在结肠癌检测中,血清核仁素敏感性为91.9%-特异性为83.8%,癌胚抗原(carcino-embryonic antigen,CEA)敏感性为68.6%-特异性为85.0%-浸润型结肠癌患者中血清核仁素水平明显高于隆起型和溃疡型(P < 0.05)-结肠癌患者血清核仁素水平与年龄-性别-肿瘤大小-分化程度-浸润程度-淋巴结转移-远处转移-TNM分期-Ducks分期均无相关性(P均 > 0.05)-结论:结肠癌患者血清核仁素检测敏感性和特异性较高,敏感性优于CEA,特异性与CEA相当,对结肠癌的诊断有潜在应用价值-

    Abstract:

    Objective:To investigate the level of nucleolin in serum of colorectal cancer patients and its clinical significance. Methods:The levels of serum nucleolin in 172 patients with colon cancer,24 patients with rectal cancer and 80 healthy controls were determined by enzyme linked immunosorbent assay (ELISA). The relationship between serum nucleolin level in colon cancer and clinical features and pathological features were analyzed. Results:The serum nucleolin level in colon cancer patients,rectal cancer patients,and healthy controls were 228.9 ± 212.4 pg/mL,115.1 ± 34.5 pg/mL and 101.1 ± 32.4 pg/mL. The serum nucleolin level in colon cancer patients was significantly higher than that in healthy controls (P < 0.001),and there was no significantly difference between rectal cancer patients and healthy controls (P > 0.05). The sensitivity and specificity of serum nucleolin detecting in colon cancer were 91.9% and 83.8%,and serum carcino-embryonic antigen (CEA)were 68.6%,85.0%,respectively. The level of nucleolin in serum of infiltrating type colorectal cancer was significantly higher than that in protruded type and ulcerative type (P < 0.05). There was no correlation with the serum nucleolin level in colon cancer and age,gender,tumor size,differentiation degree,degree of invasion,lymph node metastasis,distant metastasis,TNM stage,and Ducks stage. Conclusion:The detection of serum nucleolin level in colon cancer patients has a high sensitivity and specificity,and the sensitivity is better than CEA and the specificity is as similer as CEA. Serum nucleolin may be potential valuable for colon cancer diagnosis.

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王晓明,卢小东,严 枫,万 杰,莫冬萍.血清核仁素检测在结肠癌中的临床应用[J].南京医科大学学报(自然科学版),2016,(5):529-532

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  • 收稿日期:2016-01-07
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  • 在线发布日期: 2016-05-23
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