Objective:To evaluate the safety and effect of transcatheter closure of atrial septal defect(ASD)in patients aged over 60 years old. Methods:Fifty-one over 60-year-old patients underwent transcatheter ASD closure,and their clinic data and procedural outcome were analyzed in this study. Meanwhile,all the data and outcomes were compared with other age groups. Results:Patients above 60 years old with ASD (60ASD)accounted about 7.9%(51/647)of adult ASD patients. The incidence of atrial fibrillation in 60ASD (27.45%)was significantly higher than that of ASD patients aged 18~60 years (59ASD)(3.52%). Compared with 59ASD,the cardiac remodeling showed more obvious effects in 60ASD. Those effects included atrial and ventricular enlargement,increasing atrioventricular chamber pressure and pulmonary vascular resistance. However, the correlation analysis suggested there was weak correlation between age and pulmonary arterial pressure,left atrial diameter,right atrial diameter,left ventricular end diastolic diameter,right ventricular diastolic diameter,and pulmonary resistance (r=0.263,0.5,0.215,0.174,0.153,0.335,respectively). Successful rates of procedure and major complications didn’t show significant difference between 60ASD and 59ASD. Right cardiac remodeling after procedure was significant,as the right atrial/ventricular overload was alleviated and diameter was reduced no matter which age group was the patient in. However,the improvement of 60ASD cardiac remodeling was less than 59ASD. Conclusion:Transcatheter ASD closure is effective and safe among ASD patients over 60 years old.