文章摘要
余成啸,许冲全,王礼华,马红霞.外周血相对端粒长度与头颈部鳞癌死亡风险的关联研究[J].南京医科大学学报,2016,(6):648~652
外周血相对端粒长度与头颈部鳞癌死亡风险的关联研究
The association of relative telomere length in peripheral bloods with the death risk of head and neck squamous cell carcinoma
投稿时间:2016-05-03  
DOI:10.7655/NYDXBNS20160602
中文关键词: 头颈部鳞癌  相对端粒长度  死亡风险
英文关键词: head and neck squamous cell carcinoma  relative telomere length  the death risk
基金项目:国家自然科学基金(81473048);江苏高校优势学科建设工程项目;江苏省高等学校大学生实践创新训练计划(201310312003Z)
作者单位
余成啸 南京医科大学公共卫生学院流行病学系,江苏 南京 211166 
许冲全 南京医科大学公共卫生学院流行病学系,江苏 南京 211167 
王礼华 南京医科大学公共卫生学院流行病学系,江苏 南京 211168 
马红霞 南京医科大学公共卫生学院流行病学系,江苏 南京 211169 
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中文摘要:
      目的:探讨中国汉族人群中端粒长度与头颈部鳞癌患者死亡风险的关联?方法:应用实时荧光定量聚合酶链反应(RT-PCR)技术检测241例头颈部鳞癌患者外周血DNA端粒相对长度,结合临床信息和随访资料,进行端粒长度与头颈部鳞癌死亡风险的关联分析?通过Kaplan-Meier方法和Log-rank检验比较生存时间差异,COX比例风险回归模型估计风险比(hazard ratio,HR)及95%CI?结果:将头颈部鳞癌病例按照端粒长度的三分位数分为3组后,端粒长度由短至长的第1?2和3组的平均生存期显著增加(分别为40.46?41.76和46.18个月,趋势性P=0.009)?与相对端粒长度<1.19的患者相比,相对端粒长度>1.49的患者死亡风险显著降低(HR:0.40,95%CI:0.20~0.80)?分层分析结果表明,较长的端粒长度与头颈部鳞癌患者死亡风险的关联在<62岁的患者?女性?不吸烟者以及不饮酒者中更为显著?结论:端粒长度可能与头颈部鳞癌患者的预后存在一定关联,还需要其他更大样本的研究进一步验证?
英文摘要:
      Objective:To investigate the relationship of telomere length with the death risk of head and neck squamous cell carcinoma (HNSCC) in Chinese Han population. Methods:Relative telomere length (RTL) were measured using Real-time quantitative polymerase chain reaction (RT-PCR) technique in the peripheral blood DNA from 241 cases of HNSCC. Additionally,clinical information and follow-up data were collected for statistical analysis. Kaplan-Meier method and Log-rank test were performed to compare differences of survival time in groups with different RTL. Hazard ratios and 95% confidence interval were estimated by COX proportional hazards regression model. Results:We categorized HNSCC patients into 3 groups according to tertiles of their relative telomere length and found that the groups with longer relative telomere length had statistically increased mean survival time(40.46 vs. 41.76 vs. 46.18 months,P for trend =0.009). Compared to cases with relative telomere length <1.19,those patients with length >1.49 had significantly decreased death risk (HR:0.40,95% CI:0.20-0.80). However,after the multivariate adjustment,no association was found between RTL and death risk of HNSCC. Conclusion:Relative telomere length may be associated with prognosis of HNSCC patients,but studies with larger samples are needed to further validate such findings.
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