文章摘要
戚晓通,周 悦,王 伟,骆金华,陈 亮.食管基底细胞样鳞癌的外科治疗及临床预后分析[J].南京医科大学学报,2016,(6):735~738
食管基底细胞样鳞癌的外科治疗及临床预后分析
Surgical treatment and prognosis of basaloid squamous cell carcinoma of the esophagus
投稿时间:2015-10-13  
DOI:10.7655/NYDXBNS20160618
中文关键词: 食管基底细胞样鳞状细胞癌  肿瘤浸润深度  淋巴结转移
英文关键词: basaloid squamous cell carcinoma  tumor invasion depth  lymph nodes metastasis
基金项目:江苏省自然科学基金(BK20151589)
作者单位
戚晓通 南京医科大学第一附属医院胸心外科,江苏 南京 210029 
周 悦 南京医科大学第一附属医院胸心外科,江苏 南京 210029 
王 伟 南京医科大学第一附属医院胸心外科,江苏 南京 210029 
骆金华 南京医科大学第一附属医院胸心外科,江苏 南京 210029 
陈 亮 南京医科大学第一附属医院胸心外科,江苏 南京 210029 
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中文摘要:
      目的:研究食管基底细胞样鳞状细胞癌(basaloid squamous cell carcinoma of the esophagus,BSCCE)的临床特点?治疗方法及预后?方法:回顾分析44例BSCCE患者临床病理资料和生存回访资料,其中13例患者行扩大根治手术,31例行传统手术,分别研究与手术方式和生存预后相关的因素?结果:肿瘤部位?淋巴结切除总数与手术方式相关(P < 0.05)?全组患者中位生存时间23个月?1?3?5年生存率分别为78.94%?62.82%?56.54%?影响其生存预后的单因素及多因素COX回归分析提示肿瘤浸润深度是影响预后的独立因素(P < 0.05),手术方式和辅助治疗对患者预后影响有限(P > 0.05)?结论:BSCCE是一种恶性程度高并具有侵袭性的罕见肿瘤,根治性的手术切除结合术后辅助治疗值得推荐?其最佳治疗方案有待进一步研究证实?
英文摘要:
      Objective:To explore the clinical characteristics,treatment and prognosis of basaloid squamous cell carcinoma of the esophagus (BSCCE). Methods:Clinical data of 44 patients with BSCCE were analyzed retrospectively. There were 31 patients in the traditional surgery group and 13 patients in extended mediastinal lymphadenectomy group,respectively. The relevant factors of these two groups and the survival-prognosis were investigated. Results:The tumor location and lymph node resection were associated with the operation mode (P < 0.05). The median survival time (MST) was 23 months,and the 1-,3-,5-year survival rates were 78.94%,62.82%,56.54%,respectively. COX regression analysis indicated that the depth of invasion was independent prognostic factors (P < 0.05). However,the survival was not significantly improved in patients undergoing extended mediastinal lymphadenectomy and adjunctive therapy (P > 0.05). Conclusion:BSCCE is a rare malignant tumor with high malignancy. Radical resection followed with adjuvant therapy is recommended while the effectiveness of extended mediastinal lymphadenectomy and adjunctive therapy requires further validation for BSCCE.
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