NJ001识别抗原在多种肿瘤组织中的表达及其与肿瘤分化的关系
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国家自然科学基金(81371894);江苏省实验诊断学重点实验室(XK201114);江苏高校优势学科建设工程基金项目;教育部博导基金(20113234110012);国家临床重点专科建设项目


Expression of NJ001 recognized antigen and its association with tumor differentiation in multiple neoplasms
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    摘要:

    目的:研究NJ001识别抗原在人体内多种恶性肿瘤组织中的表达情况,并评估其与肿瘤分化的关系。方法:采用免疫组化的方法对肺腺癌-肺鳞癌-胰腺癌-乳腺癌-食管癌-胃癌-肝癌和对应的良性病变组织中NJ001识别抗原的表达进行检测,同时与肿瘤分化程度进行比较,通过半定量的方法判定结果,使用χ2检验或Fisher确切概率法进行相关性分析。结果:NJ001识别抗原在肺腺癌(88.0%)-肺鳞癌(82.2%)-胰腺癌(73.3%)和乳腺癌(57.8%)中均呈现出高表达,并且均与肿瘤分化程度显著相关(肺腺癌P < 0.001,肺鳞癌P=0.002,胰腺癌P=0.002,乳腺癌P=0.024)。结论:NJ001识别抗原有望为临床诊断肺腺癌-肺鳞癌-胰腺癌和乳腺癌及判断其分化程度提供一个新的肿瘤标志物。

    Abstract:

    Objective:To examine NJ001 recognized antigen expression in surgically resected human malignant tumor tissues,and to evaluate the relationship between its expression and tumor differentiation. Methods:NJ001 recognized antigen expression was immunohistochemically studied in lung adenocarcinoma,lung squamous carcinoma,pancreatic cancer,breast cancer,esophageal cancer,gastric cancer,liver cancer and matched non-neoplastic tissues,and all positive cases were compared on tumor differentiation. The results were scored by semiquantitative analysis,and statistical analysis was evaluated by chi-square test or Fisher exact test. Results:Expression of NJ001 recognized antigen was significantly high in lung adenocarcinoma (88.0%),lung squamous carcinoma(82.2%),pancreatic cancer(73.3%)and breast cancer(57.8%),and was significantly correlated with lower differentiation degree in all these tumors (P < 0.001 in lung adenocarcinoma;P=0.002 in lung squamous carcinoma;P=0.002 in pancreatic cancer;and P=0.024 in breast cancer). Conclusion:NJ001 recognized antigen is expected to be a tumor marker in lung adenocarcinoma,lung squamous carcinoma,breast cancer and pancreatic cancer,as well as a remarkable biomarker for identification of differentiation degree in multiple neoplasms.

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荆俊鹏,王 悦,吴 蕾,余汉中,蒋欣华,李月梅,王 芳,徐 建,顾春荣,孙瑞红,潘世扬. NJ001识别抗原在多种肿瘤组织中的表达及其与肿瘤分化的关系[J].南京医科大学学报(自然科学版),2016,(7):826-829

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  • 收稿日期:2016-04-18
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  • 在线发布日期: 2016-07-15
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