文章摘要
潘 杨,张 丽.脂蛋白相关磷脂酶A2与轻型缺血性卒中早期神经功能恶化风险分层的相关性研究[J].南京医科大学学报,2016,(8):991~994
脂蛋白相关磷脂酶A2与轻型缺血性卒中早期神经功能恶化风险分层的相关性研究
Correlation between lipoprotein associated phospholipase A2 and risk stratification of early neurological deterioration in patients with mild ischemic stroke
投稿时间:2016-04-17  
DOI:10.7655/NYDXBNS20160820
中文关键词: 轻型缺血性卒中  脂蛋白相关磷脂酶A2  早期神经功能恶化
英文关键词: mild ischemic stroke  lipoprotein associated phospholipase A2  early neurological deterioration
基金项目:南京医科大学科技发展基金面上项目(2011NJMU095)
作者单位
潘 杨 南京医科大学附属脑科医院老年医学科,江苏 南京 210029 
张 丽 南京医科大学附属脑科医院老年医学科,江苏 南京 210029 
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中文摘要:
      目的:研究脂蛋白相关磷脂酶A2(Lp-PLA2)联合改良版ABCD2评分与轻型缺血性卒中早期神经功能恶化(END)的相关性?方法:本研究共收集148例急性轻型缺血性卒中患者为研究对象,应用改良版ABCD2评分进行风险分层,ELISA法检测患者血浆Lp-PLA2水平?结果:END和无END 2组轻型缺血性卒中患者进行比较,END组Lp-PLA2水平显著升高(P < 0.05)?Lp-PLA2与改良版ABCD2评分显著相关( P <0.05)?多因素Cox回归分析结果显示ABCD2评分(≥4分)?大动脉狭窄(≥75%)及Lp-PLA2(>200 ng/mL)是轻型脑缺血卒中END复合终点事件的预测因素(P < 0.05)?结论:Lp-PLA2联合改良版ABCD2评分可提高轻型缺血性卒中END事件的风险预测能力?
英文摘要:
      Objective:To explore the correlation between Lp-PLA2 combined with modified ABCD2 score and early neurological deterioration(END) in patients with mild ischemic stroke. Methods:A total of 180 patients with acute mild ischemic stroke were recruited in this study. All patients were evaluated by improved ABCD2 score for risk stratification,and the serum Lp-PLA2 level was detected by ELISA. Results:The level of Lp-PLA2 was significantly increased compared with that in the non END group (P < 0.05) . Lp-PLA2 was significantly related with improved ABCD2 score (P < 0.05). The Cox regression logistic regression model indicated that ABCD2 score (≥4),large artery stenosis (≥75%) and Lp-PLA2 (>200 ng/mL) were the predictive factors of END composite end points in mild cerebral ischemic stroke (P < 0. 05). Conclusion:Lp-PLA2 combined with modified ABCD2 score can improve the ability to predict the risk of END events in mild ischemic stroke.
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