文章摘要
洪 音,孟 浩,徐 俊,张桁忠,潘陈玲,成佳星,徐 耀,吕 翔.血清sFlt-1、PLGF水平及比值变化预测孕妇轻度子痫前期发病的Meta分析[J].南京医科大学学报,2016,(10):1270~1276
血清sFlt-1、PLGF水平及比值变化预测孕妇轻度子痫前期发病的Meta分析
Meta-analysis of the relationship between the serum levels of sFlt-1, PLGF and their ratio for diagnosis of mild preeclampsia in pregnant women
投稿时间:2016-03-14  
DOI:10.7655/NYDXBNS20161028
中文关键词: 轻度子痫前期  胎盘生长因子  可溶性血管内皮生长因子受体-1  Meta分析
英文关键词: mild-preeclampsia  PLGF  sFlt-1  Meta-analysis
基金项目:国家自然科学基金(81471215,81271211);江苏省社会发展重点病种规范化诊疗项目(BE2015665);江苏省自然 科学基金(BK20151592);江苏省野猿猿猿冶高层次人才(2013-0077);江苏省野六大人才高峰冶(2012-ws-002);扬州市绿扬金凤领军 人才(yzlyjfjh2013CX056)
作者单位
洪 音 苏北人民医院健康管理中心,江苏 扬州 225001 
孟 浩 扬州大学医学院非编码RNA研究中心,江苏 扬州 225001 
徐 俊 苏北人民医院神经内科,江苏 扬州 225001 
张桁忠 苏北人民医院健康管理中心,江苏 扬州 225001 
潘陈玲 昆明理工大学生命科学与技术学院,云南 昆明 650000 
成佳星 苏北人民医院神经内科,江苏 扬州 225001 
徐 耀 苏北人民医院神经内科,江苏 扬州 225001 
吕 翔 苏北人民医院神经内科,江苏 扬州 225001 
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中文摘要:
      目的:探讨血清可溶性血管内皮生长因子受体-1(soluble fms-like tyrosine kinase-1,sFlt-1)?胎盘生长因子(placental growth factor,PLGF)水平及比值变化与轻度子痫前期发病关系。方法:检索万方?CNKI?PubMed?Embase和Cochrane收集1994—2016年国内外公开发表的关于血清sFlt-1?PLGF水平及比值变化与轻度子痫前期关系的中英文病例对照研究,剔除不符合标准的文献,对纳入的文章采用Review Manager 5.3软件对结果进行统计分析。结果:共纳入文献17篇,其中中文文献14篇,英文文献3篇。血清sFlt-1表达水平与轻度子痫前期的关系的异质性检验I 2 = 96%,P < 0.000 01,存在明显的异质性,合并效应SMD=4.89(95%CI:3.60~6.17),P < 0.000 01,差异有统计学意义。血清PLGF表达水平与轻度子痫前期的关系的异质性检验I 2 = 93%,P < 0.000 01,存在明显的异质性,合并效应SMD=-2.32(95%CI:-2.91~-1.72),P < 0.000 01,差异有统计学意义。轻度子痫前期组和正常对照组血清sFlt-1/PLGF比值异质性检验I 2 = 98%,P < 0.000 01,合并效应SMD=1.95(95%CI:0.50~3.40),P < 0.000 01,差异有统计学意义。结论:PLGF与轻度子痫前期的发病具有密切关系,血清sFlt-1的表达水平与轻度子痫前期有关,sFlt-1以及sFlt-1/PLGF比值可以作为辅助诊断轻度子痫前期的有效指标
英文摘要:
      Objective:To investigate the relationship between the serum levels of sFlt-1,PLGF and their ratio in mild preeclampsia. Methods:We searched Wanfang,CNKI,PubMed,Embase and Cochran,and published domestic and foreign controlled studies about the relationship between the serum levels of sFlt-1,PLGF and their ratio in mild preeclampsia from 1994 to 2014. Then,we excluded non-compliant documents,and statistically analyzed the results of included studies using Review Manager 5.3 software. Results:A total of 17 studies were included in this study,including 14 Chinese studies and 3 English studies. Heterogeneity test about the serum levels of sFlt-1 expression and the relationship between mild preeclampsia was I2=96%,P< 0.000 01,and the heterogeneity was significant. The combined effect of SMD=4.89(95%CI:3.60~6.17),P < 0.000 01,the difference was statistically significant. Heterogeneity test about the serum levels of PLGF expression and the relationship between mild preeclampsia was I2=93%,P < 0.000 01,the heterogeneity was significant. The combined effect of SMD=-2.32(95%CI:-2.91~-1.72),P < 0.000 01,the difference was statistically significant. Heterogeneity test about the serum levels of sFlt-1/PLGF ratio expression and the relationship between preeclampsia was I2=98%,P < 0.000 01,the heterogeneity was significant,the combined effect of SMD=1.95(95%CI:0.50~3.40),P < 0.000 01,the difference was statistically significant. Conclusion:PLGF is highly correlated with the occurrence and development of mild preeclampsia;the serum levels of sFlt-1 expression associated with mild preeclampsia;sFlt-1 and sFlt-1/PLGF ratio can be used as an effective index for diagnosis of mild preeclampsia.
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