文章摘要
朱晓巍,徐 湘,徐清田,成兴波.人血清睫状神经营养因子水平与2型糖尿病的关系[J].南京医科大学学报,2016,(11):1362~1367
人血清睫状神经营养因子水平与2型糖尿病的关系
The relationship between human serum ciliary neurotrophic factor and type 2 diabetes mellitus
投稿时间:2016-04-17  
DOI:10.7655/NYDXBNS20161117
中文关键词: 2型糖尿病  睫状神经营养因子  糖尿病视网膜病变  糖尿病周围神经病变
英文关键词: type 2 diabetes mellitus  ciliary neurotrophic factor  diabetic retinopathy  diabetic peripheral neuropathy
基金项目:
作者单位
朱晓巍 南京医科大学附属无锡人民医院内分泌科,江苏 无锡 214023 
徐 湘 南京医科大学附属无锡人民医院内分泌科,江苏 无锡 214023 
徐清田 苏州大学附属第一医院内分泌科,江苏 苏州 215007 
成兴波 苏州大学附属第一医院内分泌科,江苏 苏州 215007 
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中文摘要:
      目的:观察2型糖尿病及并发症与血清睫状神经营养因子(ciliary neurotrophic factor,CNTF)水平的关系?方法:将2型糖尿病患者分为无并发症37例(DM组)?视网膜病变34例(DR组)和周围神经病变30例(DPN组),并以同时段体检中心正常健康人群20例为对照?采集一般资料以及生化资料,ELISA测定CNTF水平?结果:①各组性别?年龄?身高?体重?体重指数及腰围均无显著差异;DR组?DPN组糖尿病病程?空腹血糖?糖化血红蛋白(glycosylated hemoglobin,HbA1c)及低密度胆固醇(low-density lipoprotein cholesterol,LDL-C)水平均显著高于DM组(P < 0.05);DR组肾小球滤过率估值为(86.03 ± 20.80)mL/min,显著低于DM组?DPN组;糖尿病各组CNTF水平均显著低于正常对照组(F=49.612,P < 0.001);②由Pearson相关分析可知,糖尿病合并并发症与血清CNTF水平呈负相关(r=-0.741,P < 0.001);③Logistic回归分析结果显示,CNTF?HbA1c?LDL-C水平是DR?DPN的独立危险因素?结论:2型糖尿病患者血清CNTF水平显著低于正常人,合并并发症(视网膜?周围神经)时可进一步降低CNTF水平,且CNTF是糖尿病患者发生视网膜?周围神经病变的独立危险因素之一?
英文摘要:
      Objective:This research aimed to explore the relationship between human serum ciliary neurotrophic factor and type 2 diabetes mellitus. Methods:A total of 101 patients of type 2 diabetes mellitus were separated into three groups,including DM group(n=37),DR group(n=34),and DPN group(n=30). Twenty cases of the health examination were enrolled the control group. General information was gathered including age,gender,diabetic course,height,weight and waistline. Biochemistry,C-peptide and glycosylated hemoglobin were detected by clinical laboratory and serum CNTF level was detected by ELISA. Results:①There were no significant differences in gender,age,height,weight,body mass index and waistline between groups. Diabetic course,fasting blood glucose,glycosylated hemoglobin(HbA1c),low-density lipoprotein cholesterol(LDL-C) in the group of DR and DPN were higher than those in the DM group. The level of estimated glomerular filtration rate in the DR group was(86.03 ± 20.80) mL/min,which was remarkable lower compared to the DM and DPN group. Compared with the normal group,serum CNTF in three groups with diabetes mellitus was distinctly reduced(F=49.612,P < 0.001). ②Diabetes mellitus complicated with retinopathy and peripheral neuropathy was negatively correlated with serum CNTF by Pearson correlation analysis(r=-0.741,P < 0.001). ③The result of Logistic regression analysis showed that CNTF,HbA1C and LDL-C were independent risk factors for the development of DR and DPN. Conclusion:The level of serum CNTF was significant lower in diabetic patients,and it was negatively correlated with diabetic complications. CNTF is one of the independent risk factors for diabetic retinopathy and peripheral neuropathy.
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