文章摘要
高潺潺,吴平平,金潇潇.VEGF、EGFR在原发性肝癌中的表达及其临床意义[J].南京医科大学学报,2016,(12):1436~1439
VEGF、EGFR在原发性肝癌中的表达及其临床意义
Correlation between expressions of VEGF and EGFR and clinical biological behavior in liver cancer
投稿时间:2016-06-03  
DOI:10.7655/NYDXBNS20161206
中文关键词: 血管内皮生长因子  表皮生长因子  肝癌
英文关键词: VEGF  EGFR  primary liver cancer
基金项目:
作者单位
高潺潺 东南大学附属中大医院肿瘤科,江苏 南京 210009 
吴平平 江苏省肿瘤医院肿瘤内科,江苏 南京 210009 
金潇潇 东南大学附属中大医院肿瘤科,江苏 南京 210009 
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中文摘要:
      目的:检测血管内皮生长因子(vascular endothelial factor,VEGF)和表皮生长因子(epidermal growth factor receptor,EGFR)在原发性肝癌(primary liver cancer)中的表达状况,研究两者与原发性肝癌的临床生物学行为之间的关系及两者之间的相关性?方法:采用免疫组化SP法检测VEGF?EGFR在63例原发性肝癌中的表达状况?结果:①63例原发性肝癌中,VEGF?EGFR的阳性表达率分别为63.5%?50.8%;② VEGF在原发性肝癌中的阳性表达与Edmondson病理分级?有无门静脉癌栓?肿瘤有无包膜及临床分期相关(P < 0.05),而与性别?年龄?AFP水平?HBsAg状况?有无肝硬化?组织学类型及肿块大小无关(P > 0.05);③EGFR在原发性肝癌中的阳性表达与组织学类型?Edmondson病理分级?肿块大小?肿瘤有无包膜相关(P < 0.05),而与性别?年龄?AFP水平?HBsAg状况?有无肝硬化?有无门脉癌栓及临床分期无关(P > 0.05);④在原发性肝癌中,VEGF和EGFR的表达关系呈正相关关系?结论:VEGF?EGFR在原发性肝癌的发生?发展过程中起重要作用?
英文摘要:
      Objective:To investigaee the expressions of VEGF and EGFR and their associations with the clinical biological behavior in primary liver cancer. Methods:The protein expressions of VEGF and EGFR were detected in 63 primary liver cancer by immunohistochemistry streptavidin-perosidase(SP)methods. Results:①The positive expression rate of VEGF and EGFR was 63.5% and 50.8%,respectively.②The expression of VEGF was significantly correlated with Edmondson pathologic grade,portal vein tumor thrombus,tumor capsule and clinical stage(P < 0.05),while not with sex,age,AFP level,HBsAg status,liver cirrhosis,histological type and tumor size(P > 0.05).③EGFR expression was related to histological type,Edmondson pathologic grade,tumor mass and tumor capsule(P < 0.05). No correlation was found between EGFR expression and sex,age,AFP level,HBsAg status,liver cirrhosis,portal vein tumor thrombus,clinical stage(P > 0.05). Conclusion:VEGF and EGFR play an important role in the growth and metastasis of primary liver cancer.
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