Foxp3+调节性T细胞分化发育及其功能稳定性研究进展
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国家杰出青年科学基金;国家重点基础研究发展计划(“973”项目)(2014CB541803,2014CB541903);国家自然科学基金(31200647,81330072,31370863,31170825, 81271835,31200646,81302532,31300711);上海市科委学术委员会基础研究重大重点项目(14JC1406100);上海市优秀学术带头人(A类)项目


Advances in researches on Foxp3+ regulatory T cell differentiation and its functional stability
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    摘要:

    Foxp3+调节性T细胞(Foxp3+Treg)是一类能抑制免疫系统攻击机体自身组织的一类CD4+T细胞亚群,其关键性表型特征在于表达Forkhead家族转录因子Foxp3。Foxp3在CD4+调节性T细胞的分化、发育和功能稳定的过程中发挥着重要功能。Foxp3蛋白水平变化导致的调节性T细胞功能稳定性改变与人类多种重大免疫相关疾病如感染性疾病、自身免疫病、过敏性疾病、肿瘤发生与转移、移植排斥等密切相关。研究Foxp3+调节性T细胞分化发育和功能稳定性的分子机制,将为相关免疫疾病治疗提供新思路新靶点。

    Abstract:

    Foxp3+ regulatory T cells (Foxp3+Treg) are a special subset of T cells that prevent other immune cells from attacking the body’s own tissues, and are critical for maintaining immune homeostasis. The forkhead family transcription factor Foxp3 is the master regulator of Foxp3+Treg development and differentiation as well as its functional stability. The alteration of functional stability of Treg cells caused by the changes of Foxp3 protein level has been actively involved in controlling major human diseases including infectious diseases, autoimmune diseases, anaphylactic disease, tumor progression, tumor metastasis, and transplantation immunity. Understanding the function of Foxp3 in regulatory T cells differentiation and development and its functional stability will lead to novel therapeutic approaches for relevant immunological diseases.

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赵启航,梁 瑞,李 丹,李 斌. Foxp3+调节性T细胞分化发育及其功能稳定性研究进展[J].南京医科大学学报(自然科学版),2017,(1):1-9

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  • 收稿日期:2016-01-09
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  • 在线发布日期: 2017-02-16
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