文章摘要
刘光泉,吴佳聪,徐 娟,许鹏飞,贾雪梅.D-二聚体和CA125联合检测在卵巢肿瘤诊断中的应用[J].南京医科大学学报,2017,(1):73~76
D-二聚体和CA125联合检测在卵巢肿瘤诊断中的应用
The diagnostic value of combined use of D-dimer and CA125 in ovarian cancer
投稿时间:2016-04-08  
DOI:10.7655/NYDXBNS20170115
中文关键词: 联合检测  血浆D-二聚体  血清CA125  卵巢恶性肿瘤
英文关键词: combined use  plasma D-dimer  serum CA125  ovarian malignant tumors
基金项目:国家自然科学基金面上项目(81572556);江苏省普通高校专业学位研究生实践创新计划项(JX22013371)
作者单位
刘光泉 南京医科大学附属妇产医院妇产科 江苏 南京 210004 
吴佳聪 南通市妇幼保健院妇保科江苏 南通 226081 
徐 娟 南京医科大学附属妇产医院妇产科 江苏 南京 210004 
许鹏飞 南京医科大学附属妇产医院医学研究中心江苏 南京 210004 
贾雪梅 南京医科大学附属妇产医院妇产科 江苏 南京 210004 
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中文摘要:
      目的:研究联合检测D-二聚体和CA125在卵巢恶性肿瘤早期诊断中的应用价值及D-二聚体在卵巢恶性肿瘤中的分布特点。方法:选择109例卵巢肿瘤患者,经病理确认,分为卵巢良性肿瘤组(59例)和卵巢恶性肿瘤组(50例),同时选择同期健康体检者30例。测定各组患者血清中CA125水平和血浆中D-二聚体水平。比较CA125和D-二聚体在各组织之间的表达差异。结果:D-二聚体和CA125联合检测在卵巢恶性肿瘤早期诊断中的检出率更高;D-二聚体在卵巢恶性肿瘤晚期患者中的水平明显高于早期患者;在浆液性卵巢恶性肿瘤中D-二聚体的水平明显高于非浆液性卵巢恶性肿瘤的患者。结论:联合检测D-二聚体和CA125在卵巢恶性肿瘤中的应用价值更大,尤其是晚期卵巢恶性肿瘤。
英文摘要:
      Objective: To investigate the diagnostic value of combined use of serum CA125 and plasma D-dimer in ovarian cancer. Methods: Totally 109 patients with ovarian tumor were randomly selected. According to the result of pathology examination, patients were divided into two groups, benign ovarian tumor group (59 cases) and malignant ovarian tumor group (50 cases). Thirty healthy subjects were also selected as control group during the same period. The level of serum CA125 and plasma D-dimer was measured. Results: Combined use of serum CA125 and plasma D-dimer can improve the diagnostic accuracy of ovarian malignant tumors. The level of plasma D-dimer in advanced malignant ovarian tumor patients was significantly higher than that of patients with early malignant ovarian tumor. The level of plasma D-dimer in serous ovarian cancer was also significantly higher than that of patients with not serous ovarian cancer. The diagnostic accuracy of combined use of serum CA125 and plasma D-dimer in malignant ovarian tumor is higher, especially in serous ovarian tumors. Conclusion: D-dimer combined with CA125 can be used as a more effective marker of malignant ovarian tumors, especially advanced ovarian cancer.
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