文章摘要
许余玲,金 华,张正东,王适之.6p21.1和7p15.3基因多态性与宫颈癌发生风险的研究[J].南京医科大学学报,2017,(2):252~255,260
6p21.1和7p15.3基因多态性与宫颈癌发生风险的研究
Two polymorphisms at 6p21.1 and 7p15.3 and the risk of cervical cancer
投稿时间:2016-01-13  
DOI:10.7655/NYDXBNS20170227
中文关键词: 6p21.1,7p15.3基因  宫颈癌  多态性
英文关键词: 6p21.1 and 7p15.3 gene  cervical cancers  polymorphisms
基金项目:国家自然科学基金(81302502);江苏省自然科学青年基金项目(BK20130641);教育部博士点基金(新教师类)(20130092120063);中央高校基本科研基金
作者单位
许余玲 东南大学公共卫生学院,江苏 南京 210009 
金 华 南通肿瘤医院中心实验室,江苏 南通 226000 
张正东 南京医科大学公共卫生学院,江苏 南京 211166 
王适之 东南大学公共卫生学院,江苏 南京 210009 
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中文摘要:
      目的:探讨6p21.1 rs2494938和7p15.3 rs2285947基因多态性与宫颈癌发生风险的关联性。方法:以571例宫颈癌患者和657例非宫颈癌患者(对照组)为研究对象,用 TaqMan MGB(minor grove binder)探针对6p21.1 rs2494938多态位点和7p15.3 rs2285947多态位点进行基因分型,分析不同基因型与宫颈癌发生风险的关联性。采用非条件Logistic回归分析统计该多态位点与宫颈癌遗传易感的关联性,计算相对危险度的比值比(OR)及95%置信区间(CI)。结果:rs2494938多态位点突变型GA和AA基因型频率在病例组和对照组的分布无显著差异(P=0.848)。rs2285947多态位点突变型GA和AA基因型频率在病例组和对照组的分布有显著差异(P=0.028);合并突变基因型(GA+AA)与野生型GG相比宫颈癌发生风险显著下降(OR=0.77,95%CI:0.62~0.97,P=0.025)。结论:rs2494938多态性与宫颈癌发生风险无显著关联,rs2285947多态性与宫颈癌发生风险有显著关联。
英文摘要:
      Objective:To investigate the correlation between 6p21.1 rs2494938 and 7p15.3 rs2285947 and risk of cervical cancer. Methods:A total of 571 cervical cancer patients and 657 cancer-free controls were recruited in the study. The genotypes of 6p21.1 rs2494938 and 7p15.3 rs2285947 were detected by TaqMan MGB probe method. The correlation between the SNPs and the susceptibility to cervical cancer was evaluated using unconditional logistic regression analysis,and the relative risk of odds ratio(OR)and 95% confidence interval(CI) were calculated. Results:There was no significant association between the frequencies of GA or AA among the case and control groups at SNP rs2494938 (P=0.848). There was significant association between the frequencies of GA or AA among the case and control groups at SNP rs2285947,(P=0.028),and significant reduction was found in the risk of cervical cancer between all mutation genotype(GA + AA)and wild type genotype GG(OR=0.77,95%CI:0.62~0.97,P=0.025). Conclusion:There was no significant association between the rs2494938 pleiotropy and cervical cancer susceptibility,and there was significant association between the rs2285947 pleiotropy and cervical cancer susceptibility.
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