文章摘要
武亦娴,金琳羚,孙理想,魏永越,曾晓宁,孔 辉,解卫平.103例NSCLC胸腔镜下肺癌根治术后患者临床分析[J].南京医科大学学报,2017,(3):318~321
103例NSCLC胸腔镜下肺癌根治术后患者临床分析
Clinical analysis of 103 patients with NSCLC after thoracoscopic radical resection
投稿时间:2016-07-07  
DOI:10.7655/NYDXBNS20170312
中文关键词: 非小细胞肺癌  胸腔镜下肺癌根治术  吸烟  COPD
英文关键词: non-small cell lung cancer  thoracoscopic radical resection  smoking  COPD
基金项目:国家自然科学基金(81273571);江苏高校优势学科建设工程资助(JX10231802)
作者单位
武亦娴 南京医科大学第一附属医院呼吸与危重症医学科江苏 南京 210029 
金琳羚 南京医科大学第一附属医院呼吸与危重症医学科江苏 南京 210029 
孙理想 南京医科大学第一附属医院呼吸与危重症医学科江苏 南京 210029 
魏永越 南京医科大学公共卫生学院生物统计学系江苏 南京 211166 
曾晓宁 南京医科大学第一附属医院呼吸与危重症医学科江苏 南京 210029 
孔 辉 南京医科大学第一附属医院呼吸与危重症医学科江苏 南京 210029 
解卫平 南京医科大学第一附属医院呼吸与危重症医学科江苏 南京 210029 
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中文摘要:
      目的:通过回顾性分析103例非小细胞肺癌(non-small cell lung cancer,NSCLC)患者,了解胸腔镜下肺癌根治术后患者的临床特点及影响预后的因素。方法:随访南京医科大学第一附属医院103例NSCLC胸腔镜下肺癌根治术后患者,应用χ2检验、Log-rank检验、Cox回归分析相关临床资料。结果:103例NSCLC患者的平均年龄(61.5±9.4)岁,男性多见(75.7%);腺癌为主(60.2%);Ⅰ、Ⅱ期最多(70.9%);总体1、3、5年生存率分别为96.1%、77.0%和67.3 %;术前合并慢性阻塞性肺病(chronic obstructive pulmonary disease, COPD)的肺癌患者1、3、5年生存率分别为94.1%、47.1%和40.3%,不合并COPD的肺癌患者1、3、5年生存率分别为96.5%、86.0%和72.6%;Log-rank检验分析结果显示,术前合并COPD与不合并COPD组患者生存情况差异具有统计学意义(P<0.05)。结论:NSCLC胸腔镜下肺癌根治术患者以男性居多,腺癌为主,绝大多数有吸烟史。Ⅰ期患者5年生存率为76.0%,术前合并COPD是影响NSCLC胸腔镜下肺癌根治术后预后的因素之一。
英文摘要:
      Objective: This study evaluated the clinical features and prognostic factors of patients with non-small cell lung cancer (NSCLC) who received thoracoscopic radical resection, to develop better understanding of diagnosis and treatment of NSCLC. Meth-ods: A total of 103 patients with NSCLC at stage Ⅰ-Ⅲ, who underwent thoracoscopic radical resection, were followed up by telephone interview, and the results were analyzed using Kaplan-Meier method, Log-rank test and a multivariable Cox proportional hazard model. Results: The average age of the 103 patients was 61.5±9.4 years old. Among these patients, there was a predominance of male patients (75.7%); adenocarcinoma occupied the highest proportion in all pathological types, which accounted for 60.2%; phase Ⅰ and Ⅱ occupied the highest proportion, which accounted for 70.9%. The 1-, 3- and 5-year survival rates were 96.1%, 77.0% and 67.3%, respectively. The patients with chronic obstructive pulmonary disease (COPD) presented worse survival rates (94.1%, 47.1%, and 40.3%, respectively) than those without COPD (96.5%, 86.0%, and 72.6%, respectively) (P<0.05). Conclusion: The majority of patients with NSCLC, who underwent thoracoscopic radical resection, were males with smoking, and the main pathological type was adenocarcinoma. The 5-year survival rate of patients with stage I was 76.0%. Long-term survival after thoracoscopic radical resection for patients with NSCLC is correlated with the presence of COPD or percent predicted DLCO, which can be used in the risk and benefit assessment when choosing surgery.
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