文章摘要
卢 鹏,刘 巧,陆 伟,丁晓艳,竺丽梅,羊海涛.江苏省耐多药肺结核患者痰涂片阴转影响因素的前瞻性队列研究[J].南京医科大学学报,2017,(3):368~372
江苏省耐多药肺结核患者痰涂片阴转影响因素的前瞻性队列研究
Factors affecting time to sputum smear negative conversion in multidrug-resistant tuberculosis:a prospective cohort study in Jiangsu Province,China
投稿时间:2016-09-12  
DOI:10.7655/NYDXBNS20170325
中文关键词: 痰涂片阴转  耐多药  结核病  危险因素
英文关键词: sputum smear negative conversion  multidrug-resistant  tuberculosis  risk factors
基金项目:国家科学基金项目(81302480)
作者单位
卢 鹏 南京医科大学公共卫生学院流行病与卫生统计学系江苏 南京 211166 
刘 巧 江苏省疾病预防控制中心江苏 南京 210009 
陆 伟 江苏省疾病预防控制中心江苏 南京 210009 
丁晓艳 江苏省疾病预防控制中心江苏 南京 210009 
竺丽梅 江苏省疾病预防控制中心江苏 南京 210009 
羊海涛 南京医科大学公共卫生学院流行病与卫生统计学系江苏 南京 211166
江苏省血吸虫病防治研究所江苏 无锡 214064 
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中文摘要:
      目的:探讨江苏省耐多药肺结核患者痰涂片阴转的影响因素。方法:在江苏省徐州、镇江、连云港和南通4个城市选取确诊的耐多药肺结核患者作为研究对象,分析可能对痰阴转产生影响的各种因素。结果:2011年12月—2014年3月共纳入127例耐多药肺结核患者。其中106例(83.5%)患者痰涂片阴转,中位阴转时间为145 d(四分位数间距:102~228 d)。81例(63.8%)耐多药患者治愈;46例(36.2%)耐多药患者治疗失败或死亡。吸烟(HR:0.561,95%CI:0.320~0.984,P=0.044)、氧氟沙星耐药(HR:0.556,95%CI:0.317~0.975,P=0.041)和初始涂片等级>1(HR:0.557,95%CI:0.334~0.928,P=0.025)是痰阴转的危险因素。结论:吸烟、耐氧氟沙星和初始涂片等级偏高是影响耐多药肺结核痰涂片阴转的危险因素。
英文摘要:
      Objective:To evaluate the performance of sputum smear negative conversion as an early indicator of treatment success in multidrug-resistant tuberculosis patients. Methods:This study was performed in four cities,including Xuzhou,Zhenjiang,Lianyungang, and Nantong in Jiangsu Province of China. All multidrug-resistant tuberculosis patients were successively enrolled in the study between December 2011 and March 2014 to analyze the possible factors that may affect sputum negative conversion. Results:A total of 127 patients were enrolled in our study. Among them,106 (83.5%) had a sputum smear conversion,with the median conversion time of 145 d (inter-quartile range:102 to 228 d). Besides,81(63.8%) were cured; 46(36.2%) were failed or dead. Smoking(HR=0.561,95%CI:0.320-0.984,P=0.044),ofloxacin resistance(HR=0.556,95%CI:0.317-0.975,P=0.041) and sputum smear grading>1(HR=0.557,95%CI:0.334-0.928,P=0.025) were risk factors for sputum smear conversion. Conclusion:Smoking,ofloxacin-resistance,and high smear grade are risk factors for sputum smear negative conversion in multidrug-resistant tuberculosis patients in Jiangsu Province.
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