Objective：We sought to construct hollow mesoporous silica nanoparticles(HMSN) compound drug delivery system, which can target ovarian cancer cells, and to assess the effect of this drug delivery system as well as explore the treatment effect of insulin-like growth factor receptor(IGF-1R) specific inhibitor NVP combined with doxorubicin(DOX) by HMSN delivery system. Methods: We modified carboxyl on the surface of HMSN, then loaded DOX and fluorescent NVP through mechanical mixing and the electrostatic attraction. The compound drug system was characterized by TEM, infrared spectrometer and Zeta potential. The drug release rates of DOX and fluorescence NVP were detected in different pH environment. Drug delivery system gathered in cells was observed by immunofluorescence laser scanning confocal microscope at different times. We divided this experiment into HMSN-DOX-NVP group, HMSN-DOX group and the control group, and acted on SKOV-3 cells respectively. Cell apoptosis rates and cell inhibition rates in there three groups were detected by flow cytometry. Results: Zeta potentially showed that the charge of HMSN was about -22.3 mV before modified carboxyl, and the charge of HMSN raised to -44.9 mV after modified carboxyl. The size and shape of HMSN were not changed after loaded drugs observed by TEM. The drug release rates of DOX and fluorescence NVP were gradually increased with the environmental pH value gradually reduced. HMSN-DOX-NVP and HMSN-DOX gathered in cells and gradually infiltrated into the nucleus with the prolongation of time. The cell apoptosis rate and MTT inhibition rate of the HMSN-DOX-NVP group were higher than those of the HMSN-DOX group and the free control group(P＜0.05). Conclusion: HMSN compound drug delivery system can be well gathered in cytoplasm mainly through nonspecific endocytosis and ensure pharmacological activity of the released drugs simultaneously. NVP combine with DOX can improve the killing rate of DOX for cancer cells and achieve targeted inhibition of IGF-R.