文章摘要
顾丽华,黄晓丹,季国忠.miRNA-146a基因多态性与肝癌易感性的meta分析[J].南京医科大学学报,2017,(9):1222~1226
miRNA-146a基因多态性与肝癌易感性的meta分析
Association of miRNA-146a polymorphism with hepatocellular cacinoma risk: a meta-
投稿时间:2017-02-23  
DOI:10.7655/NYDXBNS20170932
中文关键词: miRNA  基因多态性  肝癌  meta分析
英文关键词: miRNA  polymorphism  hepatocellular carcinoma  meta-analysis
基金项目:国家自然科学基金(81301823)
作者单位
顾丽华 南京医科大学第二附属医院全科医学科 
黄晓丹 消化内科江苏 南京 210011 
季国忠 南京医科大学第二附属医院全科医学科 
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中文摘要:
      目的:通过meta分析评价miRNA-146a rs2910164位点基因多态性与肝癌易感性之间的相关性。方法:系统地检索PubMed、Embase、Web of Science、中国知网以及中国生物医学文献数据库 2017年1月30日之前发表的相关文章,用总的比值比(odd ratios, OR)及相应的95%可信区间(credibility intervals, CI)来评价miRNA-146a基因多态性与肝癌易感性之间的相关性。结果:共纳入了18项病例对照研究,包括5 657例肝癌病例与6 680例健康对照。经过统计分析未发现miRNA-146a rs2910164位点的基因多态性与肝癌易感性之间存在相关性(C vs. G:OR=0.96,95%CI=0.88~1.06;GC vs. GG:OR=0.98,95%CI=0.88~1.09; CC vs. GG:OR=0.90,95%CI=0.74~1.09;GC/CC vs. GG:OR=0.95,95%CI=0.82~1.10;CC vs. GC/GG:OR=0.95,95%CI= 0.84~1.07)。结论:目前没有足够证据能够证明miRNA-146a基因多态性与肝癌易感性之间存在相关性。未来有必要在大规模和设计完善的研究中加以验证。
英文摘要:
      Objective:To assess the association between miRNA-146a rs2910164 polymorphism and HCC risk by a meta-analysis. Methods:A systematical search of studies was conducted in papers published in PubMed , Embase ,Web of Science, China National Knowledge Infrastructure(CNKI) and Chinese Biomedical Literature Database(CBM) databases before January 30, 2017. Odds ratios(OR) and 95% confidence intervals(95% CI) were used to evaluate the association between miRNA-146a polymorphism and HCC risk. Results:A total of 18 case-control studies involving 5 657 cases and 6 680 healthy controls were included in this meta-analysis, in which no association was found between miRNA-146a rs2910164 polymorphism and HCC risk in any genetic models(C versus G:OR=0.96, 95%CI=0.88~1.06;GC versus GG:OR=0.98,95%CI=0.88~1.09;CC versus GG:OR=0.90,95%CI=0.74~1.09;GC/CC versus GG:OR=0.95,95%CI=0.82~1.10;CC versus GC/GG:OR=0.95,95%CI=0.84~1.07). Conclusion: No sufficient evidence supports the association between miRNA-146a rs2910164 polymorphism with hepatocellular cacinoma risk. The conclusion should be verified in large-scale and well-designed studies in the future.
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