The pathogenesis process of glioma and normal astrocytes involved in a variety of cell ion channel alternations，different pathological types and levels，prognosis of gliomas have significant differences in ion channel alternations. Such alternations involve astrocytes to maintain their own cell cycle and intracellular environmental homeostasis，glioma malignant proliferation，metastasis，invasion，and etc. Previous studies have suggested that the above-mentioned cell ion channels can be used as a molecular target for the treatment of glioma chemotherapy，prevention of metastasis and other therapeutic usage that play an important role. The ion channel has a promising potential for the underlying point of study，molecular targeting of drug targets，and clinical molecular markers.