文章摘要
曹 航,王非一凡,张越琦,李学军.脑胶质瘤相关的细胞离子通道改变[J].南京医科大学学报,2018,(1):2~6,83
脑胶质瘤相关的细胞离子通道改变
Glioma⁃associated cell ion channel alternations
投稿时间:2017-10-20  
DOI:10.7655/NYDXBNS20180101
中文关键词: 胶质瘤  离子通道
英文关键词: glioma  ion channel
基金项目:国家自然科学基金(81472594,81770781)
作者单位
曹 航 中南大学湘雅医院神经外科湖南 长沙 410078 
王非一凡 中南大学湘雅医院神经外科湖南 长沙 410078 
张越琦 中南大学湘雅医院神经外科湖南 长沙 410078 
李学军 中南大学湘雅医院神经外科湖南 长沙 410078 
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中文摘要:
      脑胶质瘤发病过程中及正常星形胶质细胞生理状态下涉及多种细胞离子通道改变,且不同病理类型、病理级别、预后情况等的胶质瘤具有明显差异的离子通道改变特征。此类改变涉及星形细胞维持细胞周及细胞内环境稳态、胶质细胞瘤恶性增殖、转移、侵袭等多个环节。既往研究提示上述发生改变的细胞离子通道可作为胶质瘤化疗增敏、预防转移等治疗目标的分子靶点,显示了离子通道作为基础研究切入点、分子靶向药物靶点、临床分子标记的可观潜力。
英文摘要:
      The pathogenesis process of glioma and normal astrocytes involved in a variety of cell ion channel alternations,different pathological types and levels,prognosis of gliomas have significant differences in ion channel alternations. Such alternations involve astrocytes to maintain their own cell cycle and intracellular environmental homeostasis,glioma malignant proliferation,metastasis,invasion,and etc. Previous studies have suggested that the above?mentioned cell ion channels can be used as a molecular target for the treatment of glioma chemotherapy,prevention of metastasis and other therapeutic usage that play an important role. The ion channel has a promising potential for the underlying point of study,molecular targeting of drug targets,and clinical molecular markers.
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