Objective：To explore the value of dynamic susceptibility-weighted contrast-enhanced（DSC）MR imaging in differentiating glioma recurrence and cerebral radiation injury. Methods：Twenty-eight patients who had cerebral gliomas were treated with radiotherapy after operation，presenting newly abnormal enhancement. All the patients underwent routine MR，DSC perfusion. The value of rCBV and rCBF in the new enhanced lesion and the opposite white matter were measured and analyzed. Receiver operating characteristic（ROC）curve was used to find the best classification threshold，and then calculating its sensitivity，specificity and accuracy. Results： The relative rCBV and rCBF value in the recurrent lesion were 2.78 ± 1.01 and 1.89 ± 0.82，respectively， while in the radiation injured lesion were 0.76 ± 0.42 and 0.47 ± 0.31，respectively（all P＜0.05）. Analysis of ROC curve showed that：if the relative rCBV value≥1.88，the diagnosis specificity of recurrent glioma was 100.0%；if the relative rCBV value≤0.62，the diagnosis sensitivity of radiation injuries was 100.0%. The threshold of the relative rCBV value was 1.88，and the differential diagnosis sensibility，specificity，and accuracy were 94.4%，100.0% and 96.4%，respectively. If the relative rCBF value≥1.96，the diagnosis specificity of recurrent glioma was 100.0%；if the relative rCBF value≤0.45，the diagnosis sensitivity of radiation injuries was 100.0%. The threshold of the relative rCBF value was 0.85，and the differential diagnosis sensibility，specificity，and accuracy were 94.4%，90.0% and 92.8%，respectively. Conclusion：DSC MRI is helpful to differentiate glioma recurrence and cerebral radiation injury.