文章摘要
曾 斌,沈方媛,吴 慧,杨 露.甲状腺激素与乳腺癌关系探讨[J].南京医科大学学报,2018,(4):488~492
甲状腺激素与乳腺癌关系探讨
Relationship between thyroid hormone and breast cancer
投稿时间:2017-06-04  
DOI:10.7655/NYDXBNS20180412
中文关键词: 乳腺癌  甲状腺激素  发病率
英文关键词: breast cancer  thyroid hormone  incidence
基金项目:国家自然科学基金青年基金(81701709)
作者单位
曾 斌 重庆医科大学附属第二医院乳甲胰外科重庆 400010 
沈方媛 重庆医科大学附属第二医院乳甲胰外科重庆 400010 
吴 慧 重庆医科大学附属第二医院乳甲胰外科重庆 400010 
杨 露 重庆医科大学附属第二医院乳甲胰外科重庆 400010 
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中文摘要:
      目的:明确甲状腺激素与乳腺癌有无相关性。方法:收集本院2016年4—9月114例乳腺癌患者(乳癌组)和137例健康人群(对照组)的外周血,比较甲状腺激素[游离三碘甲腺原氨酸(FT3)、游离甲状腺素(FT4)、三碘甲腺原氨酸(TT3)、甲状腺素(TT4)、促甲状腺素(TSH)]水平差异。结果:体重指数(BMI)、TT3、FT3、FT4在乳癌组与对照组差异具有统计学意义(P < 0.05),乳癌组较肥胖(OR=1.112,95%CI:1.021~1.211,P=0.014)且FT4水平较高(OR=1.066,95%CI:1.008~1.126,P=0.025)。淋巴结转移者FT3、FT4、TSH水平与无淋巴结转移者间差异具有统计学意义(P < 0.05),淋巴结转移者FT3水平较高(OR=1.440,95%CI=1.030~2.012,P=0.033)。结论:乳腺癌患者甲状腺激素水平较高,特别是肥胖、淋巴结转移者。
英文摘要:
      Objective:The conflict between thyroid hormones and breast cancer has been studied for years and the purpose was to identify the relationship between thyroid hormones and breast cancer. Methods:Peripheral blood samples of 251 participants including 114 patients with breast cancer and 137 healthy controls between April 2016 and September 2016 were collected. The levels of serum thyroid hormones(TT3,FT3,TT4,FT4,and TSH)were examined to compare the differences in thyroid function tests between the patients with breast cancer and healthy population. Results:There were statistically significant differences in BMI,serum TT3,FT3 and FT4 levels between the breast cancer group and healthy control group(P < 0.05). The patients with breast cancer were more likely to have a higher BMI(OR=1.112,95%CI:1.021~1.211,P=0.014)and a higher serum FT4 level(OR=1.066,95%CI:1.008~1.126,P=0.025). There were statistically significant differences in serum FT3,FT4,TSH levels between patients with and without lymph node metastasis(P < 0.05). The breast cancer with lymph node metastasis were more likely to have a higher serum FT3 level(OR=1.440,95%CI:1.030~2.012,P=0.033). Conclusion:Breast cancer patients seem to have higher levels of serum thyroid hormones,especially with obesity or lymph node metastasis.
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