文章摘要
江 涛,吴兆映,史沛聪,杨 婷,白 津,徐溢新,宋 军.KIF4A在结直肠癌中的表达及其临床意义[J].南京医科大学学报,2018,(5):628~632,637
KIF4A在结直肠癌中的表达及其临床意义
Expression and clinical significance of KIF4A in colorectal cancer tissues
投稿时间:2017-11-09  
DOI:10.7655/NYDXBNS20180511
中文关键词: 结直肠癌  KIF4A  临床病理  预后
英文关键词: colorectal cancer  KIF4A  clinicopathological parameters  prognostic
基金项目:国家自然科学基金面上项目(81472663);江苏省研究生实践创新计划(SJCX17_0553);江苏省高层次卫生人才“六个一工程”拔尖人才科研项目(LGY2017093);江苏省“333高层次人才培养工程”(BRA2015505)
作者单位
江 涛 徐州医科大学研究生学院江苏 徐州 221004 
吴兆映 徐州医科大学研究生学院江苏 徐州 221004 
史沛聪 徐州医科大学研究生学院江苏 徐州 221004 
杨 婷 徐州医科大学研究生学院江苏 徐州 221004 
白 津 徐州医科大学肿瘤防治研究所江苏 徐州 221002 
徐溢新 徐州医科大学附属医院胃肠外科江苏 徐州 221002 
宋 军 徐州医科大学附属医院胃肠外科江苏 徐州 221002 
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中文摘要:
      目的:探讨人结直肠癌组织中染色体驱动蛋白KIF4A的表达及其临床意义。方法:收集110例手术切除的结直肠癌及相应癌旁5 cm以上结直肠黏膜组织标本,采用免疫组织化学方法检测其中KIF4A的表达情况,并分析KIF4A的表达水平与结直肠癌患者临床病理特征及其预后之间的关系。结果:结直肠癌组织中KIF4A的表达显著高于癌旁5 cm以上结直肠黏膜组织(P < 0.001);KIF4A的表达水平与结直肠癌患者的分化程度(P=0.023)、淋巴结转移(P=0.020)、远处转移(P=0.032)、TNM分期(P < 0.001)和血清癌胚抗原(CEA)水平(P=0.014)有关,而与患者性别、年龄、肿瘤大小等无关(P > 0.05)。在随访的110例结直肠癌患者中,Kaplan?Meier生存曲线显示,KIF4A高表达组的5年生存率明显低于KIF4A低表达组(P < 0.05)。单因素生存分析显示,KIF4A表达程度、肿瘤分化程度、淋巴结转移、远处转移、TNM分期及血清CEA水平与结直肠癌患者术后生存时间相关。多因素COX比例风险回归模型进一步分析显示,KIF4A表达水平、TNM分期、淋巴结转移和远处转移为结直肠癌患者预后的独立危险因素。结论:KIF4A在结直肠癌组织中高表达,并且其高表达与结直肠的侵袭转移密切相关,KIF4A对于术后结直肠癌患者的预后评估具有参考价值。
英文摘要:
      Objective:To investigate the expression of kinesin family member 4A in colorectal cancer and its clinical significance. Methods:Resection samples and related corresponding tissues of colorectal mucosa above 5 cm of 110 colorectal cancer patients were collected. The expression of KIF4A in colorectal tissues and matched adjacent noncancerous tissues was detected by immunohistochemical. The relationship of KIF4A expression with clinicopathological characteristics and follow?up data were statistically analyzed. Results:The expression of KIF4A in colorectal tissues was significantly higher than that in normal tissues(P < 0.001). The expression of KIF4A was associated with degree of tumor differentiation(P=0.023),lymph node metastasis(P=0.020),distant metastasis(P=0.032),TNM stage(P < 0.001)and serum CEA(P=0.014),but not with gender,age,tumor size(all P > 0.05). Among the 110 patients with colorectal cancer who were followed,Kaplan?Meier survival curves showed that five year’s survival rate of the high KIF4A expression group was lower than that of the low KIF4A expression group. Univariate survival analysis showed that the expression of KIF4A,degree of tumor differentiation,lymph node metastasis,distant metastasis,TNM stage and serum CEA were associated with the survival time after surgical resection. Multivariate COX proportional hazard regression model analysis further revealed that the expression of KIF4A,TNM stage,lymph node metastasis and distant metastasis were the independent risk factors for prognosis. Conclusion:KIF4A is highly expressed in colorectal cancer tissues,up?regulated expression of KIF4A is associated with metastasis and invasion of human colorectal cancers,which indicates that KIF4A may be valuable in predicting prognosis and could be a potential target for therapy of colorectal cancer.
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