Objective：To introduce the technique of reduction and internal fixation of zygomatic maxillary fracture with three-dimensional navigation technique and evaluate its therapeutic effect. Methods：A total of 10 patients with zygomatic maxillary fracture of the upper jaw were selected. Cone-beam CT（CBCT） were taken before the operation and data were imported into AccuNavi software. The mirror reduction principle，preoperative planning of fracture reduction and real-time navigation technique were used to accurately guide the reduction of the fractures at the end of the operation. CBCT was taken one month after surgery and the difference between the reference points and the sagittal and coronal planes was evaluated before and after surgery. Results：The open reduction and internal fixation of fracture reduction of all the patients were successfully performed by the three-dimensional reconstruction of surgical navigation technology. Preoperative CT data analysis showed that the D-value range between the affected side and uninjured side of 0.037-9.257 mm，and the postoperative CT data analysis showed that the D-value range of 0.000-3.490 mm. The postoperative difference was significantly lower（P＜0.001），suggesting good postoperative reduction. The dimensions of preoperative health ipsilateral 2-4 mm value ratio of 33.9%（61/180），4-6 mm ratio was 7.8%（14/180），>6 mm ratio was 6.1%（11/180）；after the dimensions of health ipsilateral difference was <4 mm，and the ratio of 2-4 mm was 3.3%（6/180）. Conclusion：Three-dimensional image processing combined with computer aided navigation can be used to guide the accurate reduction of zygomatic fracture and evaluate the postoperative aesthetic effect.