文章摘要
叶 云,支 枫,马 涛.术后结合替莫唑胺对神经胶质瘤患者血清miR⁃181b及miR⁃497的影响[J].南京医科大学学报,2018,(9):1226~1228,1251
术后结合替莫唑胺对神经胶质瘤患者血清miR⁃181b及miR⁃497的影响
Effects of temozolomide combined with postoperative treatment on serum miR⁃181b and miR⁃497 levels in patients with glioma
投稿时间:2017-02-27  
DOI:10.7655/NYDXBNS20180911
中文关键词: 替莫唑胺  神经胶质瘤  miR⁃181b  miR⁃497
英文关键词: temozolomide  glioma  miR⁃181b  miR⁃497
基金项目:国家自然科学基金(81302197)
作者单位
叶 云 常州市第一人民医院神经外科江苏 常州 213003 
支 枫 常州市第一人民医院神经外科江苏 常州 213003 
马 涛 常州市第一人民医院神经外科江苏 常州 213003 
摘要点击次数: 354
全文下载次数: 512
中文摘要:
      目的:分析神经胶质瘤患者术后结合替莫唑胺对血清miR?181b及miR?497表达的影响。方法:将收治的76例神经胶质瘤术后患者随机分为A、B两组。其中A组(38例)采用司莫司汀方法治疗,B组(38例)采用司莫司汀联合替莫唑胺的方法治疗。观察比较两组患者的临床疗效,术后 1、2、3年生存率,Karnofsky 评分。同时收集患者治疗前、治疗后的血清样本,以检测miR?181b及miR?497表达的变化。结果:B组患者的客观有效率明显高于A组,差异有统计学意义(P < 0.05);B组中位生存期以及术后1、2、3年生存率明显高于A组(P < 0.05);B组术后的Karnofsky 评分显著高于A组(P < 0.05)。术后血清miR?181b浓度明显提高[术后(162.34 ± 51.79)fmol/L vs. 术前(91.37 ± 40.41)fmol/L,P <0.05];术后血清miR?497明显提高[术后(166.23 ± 53.68)fmol/L vs. 术前(88.36 ± 36.72)fmol/L,P < 0.05]。结论:术后结合替莫唑胺能够提高神经胶质瘤患者血清miR?181b及miR?497的表达,延长患者生存期。
英文摘要:
      Objective:To explore the effects of temozolomide combined with postoperative treatment on serum miR?181b and miR?497 levels in patients with glioma. Methods:Seventy?six patients with postoperative glioma were randomly divided into two groups,namely,group A(n=38)and group B(n=38). Patients in group A were treated with semustine and those in group B were treated with semustine combined with temozolomide. After the treatment,the effective rate,1?year,2?year and 3?year survival rates,Karnofsky scores in the two groups were compared. The serum samples of patients in B group were collected to detect the changes of miR?181b and miR?497 expression before and after treatment. Results:Objective response rate and disease control rate in group B were significantly higher than those in group A(P < 0.05). The median survival time in group A was shorter than that in group B. And 1?year,2?year and 3?year survival rates after the operation in group A were significantly lower than those in group B(P < 0.05). Karnofsky scores after the treatment was significantly lower in group A than that in group B(P < 0.05). The serum levels of miR?181b were significantly increased after operation[postoperative(162.34 ± 51.79)fmol/L vs. preoperative(91.37 ± 40.41)fmol/L,P < 0.05]. The serum levels of miR?497 were significantly increased after operation[postoperative(166.23 ± 53.68)fmol/L vs. preoperative(88.36 ± 36.72)fmol/L,P < 0.05]. Conclusion:Temozolomide combined with postoperative treatment can improve the expression of miR?181b and miR?497 in serum of patients with glioma,and miR?181b and miR?497 can be used for the diagnosis and prognosis of glioma.
查看全文   查看/发表评论  下载PDF阅读器