Objective：To study the risk factors of pulmonary adenocarcinoma with venous thromboembolism（VTE），and to improve the understanding of lung adenocarcinoma with VTE. Methods：The clinical data of 2 930 patients with lung adenocarcinoma admitted to the First Affiliated Hospital of NMU from January 2012 to December 2016 were retrospectively analyzed，and 96 cases were found to have VTE. Patients with VTE were included in the VTE group. Patients without VTE were included in the non-VTE group. The risk factors of VTE in lung adenocarcinoma were analyzed. Results：Among the 2 930 cases of lung adenocarcinoma，96 cases/2 930 cases（3.3%）were associated with VTE. In the VTE group，there were 57 males and 39 females，with an average age of （60.8 ± 10.1）years. In the non-VTE group，there were 1 477 males and 1 357 females，the average age was（61.0 ± 10.5）years old. There were signicant differences in smoking，central venous catheterization，chronic pulmonary diseases and stage of lung adenocarcinoma between two groups（P < 0.05）. Multiple factor analysis suggested that the chronic pulmonary disease and Ⅲ~Ⅳ stage of lung adenocarcinoma were high risk factors for lung adenocarcinoma associated with VTE. Of the 96 patients with VTE group，26 cases（27.1%）occurred in pulmonary thromboembolism（PTE）only，51 cases（53.1%）occurred in deep vein thrombosis（DVT）only，and 19 cases（19.8%）occurred in PTE and DVT. Among 45 patients with PTE，37 cases（82.2%）showed obvious clinical symptoms，and 8 cases（17.8%）had no obvious symptoms. Among 70 patients with DVT，66 cases（94.3%）showed swelling or pain on the affected side. Seventy-one patients in VTE group were accompanied by VTE after treatment of lung cancer. For 0-3 months，3~6 month，6-9 months，9-12 months and >12 months，the number of VTE cases was 37，8，8，4 and 14，respectively. At the end of follow-up，52 cases/96 cases（54.17%）died，and the median survival time of patients with VTE was 5 months. Conclusion：There was a significant correlation between Ⅲ-Ⅳ stage of lung adenocarcinoma，chronic pulmonary disease and lung adenocarcinoma with VTE. VTE was the most likely to occur in the first 3 months of the diagnosis of lung adenocarcinoma.