文章摘要
宋卫珍,姚 欣,吴巧珍,胡晓蕴.缺血修饰白蛋白在慢性阻塞性肺疾病中的意义[J].南京医科大学学报,2018,(12):1706~1710
缺血修饰白蛋白在慢性阻塞性肺疾病中的意义
Expression of ischemia modified albumin in chronic obstructive pulmonary disease
投稿时间:2018-07-03  
DOI:10.7655/NYDXBNS20181209
中文关键词: COPD  缺血修饰白蛋白  中性粒细胞淋巴细胞比值  C反应蛋白
英文关键词: chronic obstructive pulmonary disease  ischemia⁃modified albumin  neutrophil to lymphocyte ratio  C⁃reactive protein
基金项目:国家自然科学基金面上项目(81070025)
作者单位
宋卫珍 南京医科大学第一附属医院呼吸与危重症医学科江苏 南京 210029
吴江区第一人民医院呼吸科江苏 苏州 215200 
姚 欣 南京医科大学第一附属医院呼吸与危重症医学科江苏 南京 210029 
吴巧珍 吴江区第一人民医院呼吸科江苏 苏州 215200 
胡晓蕴 吴江区第一人民医院呼吸科江苏 苏州 215200 
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中文摘要:
      目的:缺血修饰白蛋白(ischemia?modified albumin,IMA)是新近发现的氧化应激相关的炎症标志物,本研究探讨其在慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)中的血清水平。方法:回顾性分析114例健康对照组与156例COPD患者,其中包括45例稳定期、111例急性加重期(acute exacerbation of chronic obstructive pulmonary disease,AECOPD)(53例不伴呼吸衰竭、58例伴有呼吸衰竭)中IMA、中性粒细胞淋巴细胞比值(neutrophil to lymphocyte ratio,NLR)、C反应蛋白(C?reactive protein,CRP)、脉氧饱和度(pulse oxygen saturation,SpO2)的水平。结果:①稳定期、急性加重期患者均较对照组血清IMA水平升高(P < 0.05),且急性加重期患者较稳定期患者IMA水平明显升高(P < 0.05);②伴呼吸衰竭的AECOPD患者血清IMA水平显著高于不伴呼吸衰竭患者(P < 0.05);③COPD患者血清IMA与NLR及CRP水平均呈正相关(r=0.228,0.385,P均<0.05)。结论:IMA在COPD患者血清中水平明显升高,急性加重期时更加显著;血清IMA水平可能是反映COPD患者全身炎症效应的血清学指标之一。
英文摘要:
      Objective:Serum ischemia?modified albumin(IMA)is a newly inflammatory marker associated with oxidative stress,and the levels of serum IMA in chronic obstructive pulmonary disease(COPD)patients were researched in this study. Methods:A total of 156 patients were retrospectively enrolled in this study,including 45 patients with stable COPD and 111 patients with acute exacerbation of COPD(AECOPD),in which 53 patients without respiratory failure and 58 patients with respiratory failure. A total of 114 healthy participants were recruited to the control group. The levels of IMA,neutrophil to lymphocyte ratio(NLR),C?reactive protein(CRP)and pulse oxygen saturation(SpO2)were detected. Results:Compared with the control group,the levels of IMA in stable COPD group and AECOPD group were higher,especially in AECOPD patients(P < 0.05,respectively). The levels of IMA in AECOPD patients with respiratory failure were significantly higher than that in AECOPD patients without respiratory failure(P < 0.05). The levels of IMA show positive correlation with NLR and CRP in COPD patients(r=0.228,0.385,all P < 0.05). Conclusion:Our study indicated that the levels of IMA in COPD patients were significantly higher than those in healthy participants,especially in patients with AECOPD. IMA may be a potential biomarker for evaluating the inflammatory response in COPD patients.
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