文章摘要
严建军,高 伟,徐崇利,张郁青,陈广胜,连小清,周本军,李雪琦,叶笑天.磷脂酶 A2与非ST段抬高急性冠脉综合征临床相关性研究[J].南京医科大学学报,2018,(12):1711~1714
磷脂酶 A2与非ST段抬高急性冠脉综合征临床相关性研究
Association of Lp⁃PLA2 with the severity and prognosis of NSTE⁃ACS
投稿时间:2018-05-13  
DOI:10.7655/NYDXBNS20181210
中文关键词: 脂蛋白相关磷脂酶 A2  严重度  预后  非 ST段抬高急性冠脉综合征  冠心病
英文关键词: Lp⁃PLA2  severity  prognosis  NSTE⁃ACS  C
基金项目:江苏省科教强卫工程青年医学人才项目(QN?RC2016857);江办省自然科学基金青年基金(BK20171051);国家自然科学基金青年基金(81700331)
作者单位
严建军 南京医科大学附属江宁医院心内科江苏 南京 211100 
高 伟 南京医科大学附属逸夫医院老年医学科江苏 南京 211166 
徐崇利 南京医科大学附属江宁医院心内科江苏 南京 211100 
张郁青 南京医科大学附属江宁医院心内科江苏 南京 211100 
陈广胜 南京医科大学附属江宁医院心内科江苏 南京 211100 
连小清 南京医科大学附属江宁医院心内科江苏 南京 211100 
周本军 南京医科大学附属江宁医院心内科江苏 南京 211100 
李雪琦 南京医科大学附属江宁医院心内科江苏 南京 211100 
叶笑天 南京医科大学附属江宁医院心内科江苏 南京 211100 
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中文摘要:
      目的:研究脂蛋白相关磷脂酶A2(lipoprotein?associated phospholipase A2,Lp?PLA2)与非ST段抬高急性冠脉综合征(non?ST?elevation acute coronary syndromes,NSTE?ACS)血管病变严重程度以及预后之间的关系。方法:选取南京医科大学附属江宁医院心血管内科2014年1月至2015年5月经冠脉造影术确诊的NSTE?ACS患者95例,其中不稳定性心绞痛46例,非ST段抬高型心肌梗死49例。按年龄以及性别配比选取同期冠脉造影术正常的患者62例作为对照组。根据患者冠脉病变支数分为单支病变、双支病变和三支病变组。对所有患者术后随访1年,记录相关主要心血管事件(major adverse cardiovascular events,MACE)发生情况。探讨不同Lp?PLA2水平与NSTE?ACS患者预后的关系。结果:不稳定心绞痛组以及非ST抬高心肌梗死组患者Lp?PLA2水平较对照组明显增高,其中非ST抬高心肌梗死组患者较不稳定性心绞痛组升高更为显著。此外,随着病变支数增加,血浆Lp?PLA2水平也逐渐升高。发生MACE事件组患者Lp?PLA2水平明显高于未发生MACE事件对象。结论:Lp?PLA2水平与NSTE?ACS冠状动脉病变支数有密切关系,并且Lp?PLA2水平与NSTE?ACS患者发生MACE事件相关。
英文摘要:
      Objective:The aim of the present study was to evaluate the relationship of lipoprotein?associated phospholipase A2(Lp?PLA2)with the severity and prognosis of non?ST?elevation acute coronary syndromes(NSTE?ACS). Methods:We conducted a hospital?based study to examine the potential association of Lp?PLA2 with the severity and prognosis of NSTE?ACS. A total of 157 unrelated subjects(46 UAP patients,49 Non?STEMI patients and 62 non?CAD subjects as control)who underwent elective coronary angiography from January 2014 to May 2015 admitted to Department of Cardiology,the Affiliated Jiangning Hospital of NMU. Results:We observed that the plasma levels of Lp?PLA2 were significantly higher among non?ACS patients compared to non?CAD subjects,moreover,its level is most high in Non?STEMI patients. There was also a highly remarkable association of Lp?PLA2 with double?vessel and triple?vessel disease when patients were divided into subgroups based on the number of diseased vessels. After 1?year follow up,we found that Lp?PLA2 levels were also related to events of MACE with statistical significance. Conclusion:Our results suggest that Lp?PLA2 is associated with the severity and prognosis of NSTE?ACS.
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