文章摘要
夏丹丹,席晓薇.IL⁃15联合HPV基因疫苗治疗宫颈癌的前景[J].南京医科大学学报,2019,(3):436~441
IL⁃15联合HPV基因疫苗治疗宫颈癌的前景
Prospect of IL⁃15 combined with HPV gene vaccine for cervical cancer
投稿时间:2017-04-22  
DOI:10.7655/NYDXBNS20190326
中文关键词: HPV  基因疫苗  IL⁃15  免疫治疗  宫颈癌
英文关键词: HPV  gene vaccine  IL⁃15  immunotherapy  cervical cancer
基金项目:
作者单位
夏丹丹 南京医科大学附属常州妇幼保健院妇产科江苏 常州 213003 
席晓薇 上海交通大学附属上海市第一人民医院妇产科上海 201600 
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中文摘要:
      宫颈癌是妇科三大恶性肿瘤之一,其高发生率、高复发率、高转移率使其成为很多研究的重点。研究已明确持续性人类乳头瘤状病毒(human papilloma virus,HPV)感染,尤其是高危型HPV感染是宫颈癌发生的主要病因。目前常用的治疗方法包括:手术、放疗、化疗、免疫治疗等。而HPV 基因疫苗,尤其是以E7基因为靶基因的疫苗,能够诱导特异性细胞免疫反应,控制肿瘤生长,成为目前宫颈癌治疗方法的研究热点。但是基因疫苗应用于人体时往往存在免疫应答减弱的问题,而利用白细胞介素?15(interleukin?15,IL?15)作为基因疫苗的佐剂,促进抗原特异性免疫应答,能够显著提高免疫原性。文章就IL?15联合HPV基因疫苗治疗宫颈癌的应用进展进行综述,探讨其应用的可行性及对宫颈癌免疫治疗的价值。
英文摘要:
      Cervical cancer is one of the three gynecological malignancies. Its high incidence,recurrence rate and transfer rate make it as a focus of lots of research. Previous research has clearly confirmed that infection of persistent human papilloma virus(HPV),especially the high?risk HPV infection,is the major cause of cervical cancer. The most commonly used treatments include surgery,radiotherapy,chemotherapy,immunotherapy,etc. The HPV gene vaccine,particularly in the target of E7 gene,can induce an specific immune response to control tumor growth,and it has been a research hot spot on the treatment of cervical cancer. But there is a common problem of reduced immunogenicity of gene vaccine when it is applied to the human body. Interleukin?15(IL?15)gene as a vaccine adjuvant used to promote antigen?specific immune responses can significantly improve immunogenicity. The prospect of IL?15 combined with HPV gene vaccine in the treatment of cervical cancer is reviewed,and the feasibility of its application and the value of immunotherapy in treatment of cervical cancer are discussed after consulting literature.
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