文章摘要
杨 静,戚志强,周 红,戴 骏,史兆春,董海蓉.中性粒⁃淋巴细胞比值对急性脑梗死患者颅内外动脉狭窄的预测研究[J].南京医科大学学报,2019,(6):890~893
中性粒⁃淋巴细胞比值对急性脑梗死患者颅内外动脉狭窄的预测研究
Prediction of intracranial and extracranial stenosis in patients with acute cerebral infarction by neutrophil to lymphocyte ratio
投稿时间:2018-04-15  
DOI:10.7655/NYDXBNS20190619
中文关键词: 中性粒⁃淋巴细胞比值  急性脑梗死  动脉粥样硬化  危险因素  ROC曲线分析
英文关键词: neutrophils to lymphocyte ratio  acute cerebral infarction  atherosclerosis  risk factors  analysis of ROC curve
基金项目:苏州市科技发展计划项目(SYSD2015046);吴江区科教兴卫项目(WWK201619);吴江区科教兴卫项目(WWK201716);苏州市吴江区临床医学专家团队引进项目(WJYJTD201802)
作者单位
杨 静 南京医科大学附属江苏盛泽医院神经内科江苏 苏州 215200 
戚志强 南京医科大学附属江苏盛泽医院神经内科江苏 苏州 215200 
周 红 南京医科大学附属江苏盛泽医院神经内科江苏 苏州 215200 
戴 骏 南京医科大学附属江苏盛泽医院神经内科江苏 苏州 215200 
史兆春 南京医科大学第一附属医院神经内科江苏 南京 210029 
董海蓉 南京医科大学附属江苏盛泽医院神经内科江苏 苏州 215200 
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中文摘要:
      目的:探讨中性粒?淋巴细胞比值(neutrophil to lymphocyte ratio,NLR)对急性脑梗死患者颅内外动脉狭窄的预测价值,为急性脑梗死颅内外动脉狭窄的预测和防治提供参考。方法:采用回顾性分析,纳入南京医科大学第一附属医院神经内科住院的患者共145例,根据颅内外动脉狭窄情况分成2组,其中颅内外动脉狭窄率<50%为对照组,95例;狭窄率≥50%为狭窄组,50例。收集基线资料及血液检测指标并进行统计分析。结果:急性脑梗死患者狭窄组年龄、白细胞计数、中性粒细胞计数、NLR水平高于对照组(P < 0.05),淋巴细胞计数狭窄组低于对照组(P < 0.05);Logistic回归显示,NLR为急性脑梗死患者颅内外动脉粥样硬化性狭窄的危险因素(OR=1.492,P < 0.001);ROC曲线分析显示,白细胞、中性粒细胞、淋巴细胞、三因素联合指标及NLR的曲线下面积(AUC)分别为0.658、0.718、0.631、0.725和0.739,NLR最佳诊断值为2.23。结论:NLR对急性脑梗死患者颅内外动脉狭窄具有一定的预测作用。
英文摘要:
      Objective:A predictive value of neutrophil to lymphocyte ratio(NLR)for intracranial and extracranial artery stenosis in patients with acute cerebral infarction was explored to provide a reference for prediction and prevention of intracranial and extracranial artery stenosis in acute cerebral infarction. Methods:In this study,a total of 145 patients were enrolled in the Department of Neurology of the First Affiliated Hospital of Nanjing Medical University. Patients with ntracranial and extracranial artery stenosis were separated into 2 groups. The rate of intracranial and extracranial artery stenosis <50% was 95,and the stenosis rate of >50% was 50. Collection of baseline data and blood test indicators. All data were statistically analyzed by SPSS 19 software. Results:The age,white blood cell count,neutrophil count and NLR level in the patients with acute cerebral infarction were significantly higher than those in the control group,the differences were statistically significant. Lymphocyte count in the stenosis group was lower than that in the control group,the difference was statistically significant(P < 0.05). Logistic regression showed that NLR(OR=1.492,P < 0.001)accounts for a risk factor for intracranial and extracranial atherosclerotic stenosis in patients with acute cerebral infarction. The ROC curve analysis showed that the area under the curve of leucocyte was 0.658,the AUC of neutrophils was 0.718,the lymphocyte AUC was 0.631,the combined index AUC is 0.725,and the NLR level AUC was 0.739. The best diagnostic value of NLR was 2.23. Conclusion:NLR plays a predictive role in intracranial and extracranial artery stenosis in patients with acute cerebral infarction.
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