文章摘要
罗 明,郑 蕤,孙浩亮,倪布清,邵永丰.左室后壁厚度用于评估主动脉瓣狭窄患者瓣膜钙化情况的研究[J].南京医科大学学报,2019,(6):894~898
左室后壁厚度用于评估主动脉瓣狭窄患者瓣膜钙化情况的研究
Valve calcification were evaluated by left ventricular posterior wall thickness in patients with aortic stenosis
投稿时间:2019-01-08  
DOI:10.7655/NYDXBNS20190620
中文关键词: 钙化性主动脉瓣  左室后壁厚度  钙化程度  EF值
英文关键词: calcified aortic valve  left ventricular posterior wall thickness  calcification degree  EF value
基金项目:江苏省自然科学基金(BK20151590)
作者单位
罗 明 南京医科大学第一附属医院心脏大血管外科江苏 南京 210029 
郑 蕤 南京医科大学第一附属医院心脏大血管外科江苏 南京 210029 
孙浩亮 南京医科大学第一附属医院心脏大血管外科江苏 南京 210029 
倪布清 南京医科大学第一附属医院心脏大血管外科江苏 南京 210029 
邵永丰 南京医科大学第一附属医院心脏大血管外科江苏 南京 210029 
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中文摘要:
      目的:通过分析钙化性主动脉瓣疾病患者的左室后壁(left ventricle post wall,LVWP)厚度,评价患者瓣膜钙化的严重程度以及预后情况。方法:通过免疫组化染色、光密度半定量分析以及RT?PCR检测分析60例主动脉瓣钙化患者(分为轻、中、重主动脉瓣狭窄3组)的瓣膜组织钙化程度,比较各患者术前术后的射血分数(ejection fraction,EF)变化值,评估LVWP对判断有无手术指征以及预后的作用。结果:分析不同程度瓣膜狭窄组的LVWP,轻、中、重度瓣膜狭窄组两两对比,LVWP厚度依次增加,差异均有统计学意义。通过对瓣膜组织进行Von Kossa染色后半定量分析以及RT?PCR分析,LVWP轻、中、重度增厚组钙化程度依次加重,差异均有统计学意义。通过对患者手术前后EF差值分析,LVWP中度增厚患者的EF差值比LVWP轻度增厚患者大,差异有统计学意义。LVWP重度增厚患者的EF增加值与LVWP中度增高患者比较,差异无统计学意义。结论:LVWP可以用来预估主动脉瓣瓣膜的钙化程度,对于非主动脉瓣重度钙化患者,LVWP值越大,手术获益也越大。
英文摘要:
      Objective:This study aims to analyze the severity of left ventricular posterior wall(LVPW) in patients with calcific aortic valve disease,and to evaluate the severity of the lesion and prognosis. Methods:Immunohistochemical staining,semi?quantitative analysis of optical density and RT?PCR were used to detect the calcification degree of valvular tissue in 60 patients with aortic valve calcification,who were divided into mild,moderate and severe aortic stenosis groups. The changes of ejection fraction(EF) before and after operation were compared,and the role of left ventricle post wall(LVWP) in judging the indication of operation and prognosis was evaluated. Results:LVWP in different degree of stenosis group was analyzed,and LVWP in mild,moderate and severe stenosis group was increased in turn,the difference was statistically significant. Through the semi?quantitative analysis of Von Kossa staining of valve tissue and RT?PCR analysis,the calcification degree of LVPW mild,medium and severe thickening group increased in turn,and the difference was statistically significant. The EF difference before and after surgery of patients with LVPW medium thickening was more than that of patients with LVPW mild thickening,and the difference was statistically significant. There was no significant difference in the EF increase in patients with LVPW severe thickening and patients with LVPW medium thickening. Conclusion:LVPW can be used to estimate the approximate degree of aortic valve calcification. For patients with severe calcification of non?aortic valve,the greater the LVPW value,the greater the benefit of surgery.
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